3-(4-Bromophenyl)-2,2-difluorobicyclo[1.1.1]Pentane-1-carboxylic acid CAS 2374237-98-4

Purity 97%+In StockPharmaceutical Standards
CAS No.2374237-98-4
Molecular FormulaC12H9BrF2O2
Molecular Weight303.10 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-(4-Bromophenyl)-2,2-difluorobicyclo[1.1.1]Pentane-1-carboxylic acid CAS 2374237-98-4 chemical structure

Description

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

3-(4-Bromophenyl)-2,2-difluorobicyclo[1.1.1]Pentane-1-carboxylic acid (CAS 2374237-98-4) is a high-purity analytical reference standard with the molecular formula C12H9BrF2O2 and a molecular weight of 303.10 g/mol.

The molecular framework of 3-(4-Bromophenyl)-2,2-difluorobicyclo[1.1.1]Pentane-1-carboxylic acid (C12H9BrF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

Physical & Chemical Properties

Molecular FormulaC12H9BrF2O2
Molecular Weight303.10 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1999
Halogen ContentF/Br-containing

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