Ambroxol Impurity 59 CAS 2376577-10-3
| CAS No. | 2376577-10-3 |
| Molecular Formula | C15H20Br2N2O |
| Molecular Weight | 404.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ambroxol Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Ambroxol Impurity 59 (CAS 2376577-10-3), a pharmacopoeial impurity reference standard (molecular formula C15H20Br2N2O, MW 404.14 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ambroxol Impurity 59 (C15H20Br2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H20Br2N2O |
| Molecular Weight | 404.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Ambroxol Standards
- Ambroxol Impurity 66 (CAS CATO-C4X-108566)
- Ambroxol impurity 69 (CAS CATO-C4X-108569)
- Ambroxol impurity 112 (CAS CATO-C4X-1085112)
- Ambroxol Impurity 57 (CAS CATO-C4X-108557)
- Ambroxol Impurity 94 (CAS CATO-C4X-108594)
- Ambroxol Impurity 52 (CAS CATO-C4X-108552)
- Ambroxol-D4 N-nitroso (CAS CATO-C4X-1085111)
- Ambroxol Cyclic Impurity-d5 Dihydrochloride (CAS 1794752-24-1)
Recommended Standards
- Dimethyl 1-(4-fluorophenyl)-5-iodo-1H-pyrazole-3,4-dicarboxylate (CAS 618442-04-9)
- 2,2,3,3,4,4,4-Heptafluorobutyl (4,4,5,5,5-pentafluoropentyl) carbonate (CAS 1980048-79-0)
- Dimethyl 1-(2-fluorophenyl)-5-iodo-1H-pyrazole-3,4-dicarboxylate (CAS 618444-07-8)
- 3-Fluoropropyl (2,2,3,3,4,4,5,5,6,6,6-undecafluorohexyl) carbonate (CAS 1980085-56-0)
- Ulipristal Impurity 3 (CAS 159681-66-0)
- Propiverine Impurity 1 (CAS CATO-C4X-17401)
- Netupitant Impurity 39 (CAS CATO-C4X-122339)
- Fasudil Impurity 25 (CAS CATO-C4X-136525)
- 3-Bromo-2,5,6-trifluorobenzamide (CAS 1506289-36-6)
- methyl 4-[(2-methoxy-2-oxoethyl)sulfanyl]butanoate (CAS 38555-40-7)
- 3-Methyl-5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 1443278-81-6)
- 5-Chloro-6-cyclopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 1135283-62-3)
- Chlorprothixene impurity 3 (CAS 88658-02-0（HCl）)
- D-allo-Thr5-Semaglutide (CAS CATO-C4X-2226243)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com