Ambroxol Impurity 66 CAS CATO-C4X-108566
| CAS No. | CATO-C4X-108566 |
| Molecular Formula | C14H16Br2N2O2 |
| Molecular Weight | 404.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Ambroxol Impurity 66 (CAS CATO-C4X-108566), a pharmacopoeial impurity reference standard (molecular formula C14H16Br2N2O2, MW 404.10 g/mol) used for the identification and quantification of trace impurities in APIs.
Ambroxol Impurity 66 (C14H16Br2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Ambroxol Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H16Br2N2O2 |
| Molecular Weight | 404.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Ambroxol Standards
- Ambroxol Impurity 59 (CAS 2376577-10-3)
- Ambroxol impurity 69 (CAS CATO-C4X-108569)
- Ambroxol impurity 112 (CAS CATO-C4X-1085112)
- Ambroxol Impurity 57 (CAS CATO-C4X-108557)
- Ambroxol Impurity 94 (CAS CATO-C4X-108594)
- Ambroxol Impurity 52 (CAS CATO-C4X-108552)
- Ambroxol-D4 N-nitroso (CAS CATO-C4X-1085111)
- Ambroxol Cyclic Impurity-d5 Dihydrochloride (CAS 1794752-24-1)
Recommended Standards
- 3,6-Bis(5-bromothiophen-2-yl)-1,2,4,5-tetrazine (CAS 1279083-60-1)
- ((2-(4-Bromophenoxy)-5-nitrophenyl)(hydroxy)methyl)phosphonic acid (CAS 204130-08-5)
- 3,5-Bis(perfluoropropyl)-1H-pyrazole (CAS 1030269-34-1)
- 1-(Tetrahydro-2H-pyran-2-yl)-3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1256360-29-8)
- Trelagliptin Impurity 9 (CAS 1938080-44-4)
- Oseltamivir Impurity 132 (CAS 162252-43-9)
- Nizatidine impurity 17 (CAS CATO-C4X-138017)
- 4-Aminothiazole-2-carbonitrile (CAS 1198154-95-8)
- 4-Ethyl-1H-imidazole-1,2-diamine (CAS 694432-04-7)
- 1-(3-Methyl-6-nitro-1H-indazol-1-yl)pentan-1-one (CAS 62235-21-6)
- 1-[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]ethan-1-amine hydrochloride (CAS 1384429-93-9)
- 3-(2,4-Dichlorobenzoyl)propionic Acid (CAS 58457-57-1)
- 3-Methyl-1-(methylamino)pentan-2-ol (CAS 1310144-53-6)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
Why CATO?
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