4-Cyano-2,3-difluorophenylboronic acid CAS 2377608-51-8
| CAS No. | 2377608-51-8 |
| Molecular Formula | C7H4BF2NO2 |
| Molecular Weight | 182.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 4-Cyano-2,3-difluorophenylboronic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 182.92 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-Cyano-2,3-difluorophenylboronic acid (CAS 2377608-51-8) is a high-purity analytical reference standard with the molecular formula C7H4BF2NO2 and a molecular weight of 182.92 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Cyano-2,3-difluorophenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4BF2NO2 |
| Molecular Weight | 182.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cyano Standards
- (2-Cyano-3,6-difluorophenyl)boronic acid (CAS 1357163-26-8)
- (4-cyano-2,5-difluorophenyl)boronic acid (CAS 1628442-75-0)
- (2-Cyano-4,5-difluorophenyl)boronic acid (CAS 2199440-55-4)
- (3-Cyano-4,5-difluorophenyl)boronic acid (CAS 2199440-57-6)
- (4-Cyano-3,5-difluorophenyl)boronic acid (CAS 861710-03-4)
- 4-Cyano-2,6-difluorophenylboronic acid (CAS 2199440-52-1)
- (3-CYANO-2,4-DIFLUOROPHENYL)BORONIC ACID 2,4-DIFLUORO-3-CYANOPHENYLBORONIC ACID 871940-31-7 BC001248 BORONIC ACID, B-(3-CYANO-2,4-DIFLUOROPHENYL)- (CAS 871940-31-7)
- (2-Cyano-2-(ethoxycarbonyl)cyclopropyl)boronic acid (CAS 2225153-58-0)
Recommended Standards
- (3-Hydroxy-5-nitrophenyl)boronic acid (CAS 737001-07-9)
- (4-Hydroxy-3-nitrophenyl)boronic acid (CAS 850568-75-1)
- 1,1-Dichloro-2,3,3,3-tetrafluoroprop-1-ene (CAS 2804-55-9)
- 2-[8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl]phenylmagnesium bromide 0.25 M in Tetrahydrofuran (CAS 1187164-30-2)
- 3-Hydroxy-6,7-dimethoxy-1-methylisoquinoline-4-carbaldehyde (CAS 1447963-47-4)
- 3-(5-Chloro-1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1h-pyrazol-4-yl)acrylic acid (CAS 1006441-83-3)
- 1-(Benzyloxy)-4-ethoxybenzene (CAS 69697-44-5)
- 2-Chloro-5-((trifluoromethyl)thio)pyrazine (CAS 1206524-19-7)
- Methyl 2-(aminomethyl)-1,3-thiazole-5-carboxylate hydrochloride (CAS 2126178-66-1)
- 3,5-Dichloro-2-fluoropyrazine (CAS 2253674-32-5)
- N-Methoxy-N,3-dimethylisoxazole-5-carboxamide (CAS 173305-18-5)
- 1-[2-(methylsulfanyl)phenyl]propan-2-one (CAS 27350-24-9)
- 2-Fluoroisobutyric anhydride (CAS 1263376-40-4)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
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