ethyl 7-hydroxy-4-oxo-4H-chromene-2-carboxylate CAS 23866-72-0
| CAS No. | 23866-72-0 |
| Molecular Formula | C12H10O5 |
| Molecular Weight | 234.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
ethyl 7-hydroxy-4-oxo-4H-chromene-2-carboxylate (CAS 23866-72-0), molecular formula C12H10O5 and molecular weight 234.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of ethyl 7-hydroxy-4-oxo-4H-chromene-2-carboxylate (C12H10O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10O5 |
| Molecular Weight | 234.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
Related ethyl Standards
- Ethyl 7-hydroxy-2-oxo-2H-chromene-4-carboxylate (CAS 1084-45-3)
- Ethyl 4-hydroxy-2-oxo-2h-chromene-3-carboxylate (CAS 1821-20-1)
- 2-(7-Hydroxy-8-methyl-2-oxo-2h-chromen-4-yl)acetic acid (CAS 68747-36-4)
- 6-Acetyl-5-hydroxy-2-methylbenzofuran-3-carboxylic acid (CAS 63529-83-9)
- 7-Hydroxy-4-methylcoumarin-3-acetic acid (CAS 5852-10-8)
- 7-Hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde (CAS 7338-51-4)
- Ethyl 5-hydroxy-2-oxo-2H-chromene-3-carboxylate (CAS 70160-47-3)
- Ethyl 6-hydroxy-2-oxo-2H-chromene-3-carboxylate (CAS 70160-51-9)
Recommended Standards
- Ethyl 8-hydroxy-4-oxo-4H-chromene-2-carboxylate (CAS 53873-72-6)
- Malvone A (CAS 915764-62-4)
- Ethyl 5-(furan-2-carbonyl)furan-2-carboxylate (CAS 890100-54-6)
- Methyl ((2-oxo-2H-chromen-7-yl)oxy)acetate (CAS 24416-76-0)
- N-[4-(Diethylamino)-2-hydroxybenzylidene]-2-hydroxybenzohydrazide (CAS 316130-82-2)
- Methyl 3-Oxo-3-[4-(trifluoromethoxy)phenyl]propionate (CAS 1435444-74-8)
- (6-Cyano-1H-indol-2-yl)boronic acid (CAS 1286777-08-9)
- 4-(3-Pyridin-4-yl-propyl)-pyridine 1-oxide (CAS 865075-04-3)
- Isavuconazole Impurity 237 (CAS 60695-12-7)
- 5-Bromo-N-(pyridin-4-yl)thiophene-2-carboxamide (CAS 911466-87-0)
- 3-(tert-Butoxy)-5-(trifluoromethyl)aniline (CAS 1369841-47-3)
- 2,2-Diethylbutanenitrile (CAS 34579-77-6)
- 4-(Difluoromethyl)-6-methoxy-3-(trifluoromethyl)picolinic acid (CAS 1806957-44-7)
- Semaglutide Impurity 15 (CAS CATO-C4X-222615)
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