2-Chloro-N-(3,5-dimethylisoxazol-4-yl)acetamide CAS 23891-86-3
| CAS No. | 23891-86-3 |
| Molecular Formula | C7H9ClN2O2 |
| Molecular Weight | 188.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-N-(3,5-dimethylisoxazol-4-yl)acetamide (CAS 23891-86-3) is a high-purity analytical reference standard with the molecular formula C7H9ClN2O2 and a molecular weight of 188.61 g/mol.
The molecular framework of 2-Chloro-N-(3,5-dimethylisoxazol-4-yl)acetamide (C7H9ClN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H9ClN2O2 |
| Molecular Weight | 188.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 2-Chloro-N-(3,4-dimethylisoxazol-5-yl)acetamide (CAS 69000-38-0)
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- 2-Chloro-5-(2-methoxyethoxy)pyrimidine (CAS 61533-68-4)
- 2-Chloro-n-(5-methyl-1,2-oxazol-3-yl)propanamide (CAS 746608-25-3)
- 2,4-Dichloro-8-fluoro-6,7-dimethoxyquinazoline (CAS 1515883-85-8)
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- 5-(4,5-Dimethoxy-2-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one (CAS 1216654-38-4)
- (3-Iodophenyl)(methyl)sulfane (CAS 130416-73-8)
- 5-(2-Aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxylic acid (CAS 951784-19-3)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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