5-(2-Aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxylic acid CAS 951784-19-3
| CAS No. | 951784-19-3 |
| Molecular Formula | C15H10ClFN4O2 |
| Molecular Weight | 332.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(2-Aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxylic acid.
CATO supplies 5-(2-Aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxylic acid (CAS 951784-19-3), a certified reference material (molecular formula C15H10ClFN4O2, MW 332.72 g/mol) for analytical method development and quality control.
The molecular framework of 5-(2-Aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxylic acid (C15H10ClFN4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-(2-Aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10ClFN4O2 |
| Molecular Weight | 332.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Aminopyrimidin Standards
- 5-(2-Aminopyrimidin-4-yl)-2-(2-chloro-5-fluorophenyl)-1H-pyrrole-3-carboxylic acid (CAS 951784-17-1)
- 1-[2-(4-aminopyrimidin-2-yl)-3,4-dihydro-1H-isoquinolin-5-yl]-5-methyl-triazole-4-carboxylic acid (CAS 1334203-50-7)
- (6-Aminopyrimidin-4-yl)-N-(tert-butoxycarbonyl)carbamic acid tert-butyl ester (CAS 1364663-35-3)
- 5-((4-Aminopyrimidin-2-yl)thio)-2-pentyl-2-phenylcyclopentanone (CAS 61631-34-3)
- (R)-4-(1-(2-Aminopyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol (CAS 1202764-61-1)
- 5-(2-Aminopyrimidin-4-yl)-2-(5-methylthiophen-2-yl)-1H-pyrrole-3-carboxylic acid (CAS 951784-27-3)
- 3-(2-Aminopyrimidin-4-yl)-1-(4-chlorophenyl)pyridazin-4(1H)-one (CAS 690211-52-0)
- 5-(2-Aminopyrimidin-4-yl)-4-methyl-N-(p-tolyl)thiazol-2-amine (CAS 1209969-02-7)
Recommended Standards
- 2-chloro-N-{4-[(trifluoromethyl)sulfanyl]phenyl}nicotinamide (CAS 1023562-09-5)
- 1-[(2-Chloro-4-fluorophenyl)methyl]-5-(pyridin-4-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1338667-52-9)
- 3-[(4-Chlorophenyl)sulfanyl]-5-(trifluoromethyl)pyridine-2-carboxamide (CAS 338406-73-8)
- 1-(2-Chloro-6-methyl-4-sulfophenyl)-5-oxo-4,5-dihydro-1H-pyrazole-3-carboxylic acid (CAS 125437-42-5)
- 2-Bromo-6-iodobenzo[d]thiazole (CAS 412923-37-6)
- 3-(3-Nitrophenyl)isoxazole (CAS 4264-04-4)
- (s)-n-(2,6-Dioxotetrahydro-2h-pyran-3-yl)-2,2,2-trifluoroacetamide (CAS 1535-57-5)
- Ethyl (chloromethyl)(methyl)carbamate (CAS 6807-45-0)
- n-Ethyl-3,4-dimethylaniline (CAS 27285-20-7)
- (5-Bromo-2,3-difluoro-4-methylphenyl)methanol (CAS 2484889-29-2)
- Pentane-2-sulfonamide (CAS 17854-62-5)
- 1,3-Bis(2,4-dichlorophenyl)propane-1,3-dione (CAS 942358-08-9)
- Tezosentan (CAS 180384-57-0)
- Uremic Pentapeptide (CAS 71494-20-7)
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