Vonoprazan Impurity N18 CAS 2389131-50-2
| CAS No. | 2389131-50-2 |
| Molecular Formula | C18H17FN2O4S |
| Molecular Weight | 376.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Vonoprazan Impurity N18 (CAS 2389131-50-2), a pharmacopoeial impurity reference standard (molecular formula C18H17FN2O4S, MW 376.40 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Vonoprazan Impurity N18 (C18H17FN2O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17FN2O4S |
| Molecular Weight | 376.40 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 292 (CAS CATO-C4X-1020292)
- Vonoprazan Impurity 224 (CAS CATO-C4X-1020224)
- Vonoprazan Impurity 260-D3 (CAS CATO-C4X-1020260)
- Vonoprazan Impurity 281 (CAS 3058423-29-0)
- Vonoprazan Impurity 190 (CAS CATO-C4X-1020190)
- Vonoprazan Impurity 176 (CAS 2932441-73-9)
- Vonoprazan Impurity 303 (CAS CATO-C4X-1020303)
- Vonoprazan Impurity 257 (CAS CATO-C4X-1020257)
Recommended Standards
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- ethyl (S)-2-(((S)-1-((2,5-dioxopyrrolidin-1-yl)oxy)-1-oxopropan-2-yl)amino)-4-phenylbutanoate (CAS 89371-34-6)
- (S)-2-((S)-6-Amino-2-((2S,3R)-2-amino-3-hydroxybutanamido)hexanamido)pentanedioic acid (CAS 122605-96-3)
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- 2-(2-Amino-1,3-thiazol-4-yl)-N-methylacetamide (CAS 640768-50-9)
- 3-(3-Chlorophenyl)morpholine hydrochloride (CAS 2225141-15-9)
- 2-Fluoro-3-methyl-5-(pyridin-3-yl)pyridine (CAS 1214339-11-3)
- Hexahydro-1H-thieno[3,4-c]pyrrole hydrochloride (CAS 1378710-42-9)
- 2-Nitrophloroglucinol (CAS 16600-92-3)
- 3-Benzyl-5-((5-bromofuran-2-yl)methylene)-2-thioxothiazolidin-4-one (CAS 63618-71-3)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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