2-Formyl-4-(trifluoromethyl)benzoic acid CAS 23984-83-0
| CAS No. | 23984-83-0 |
| Molecular Formula | C9H5F3O3 |
| Molecular Weight | 218.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Formyl-4-(trifluoromethyl)benzoic acid (CAS 23984-83-0), molecular formula C9H5F3O3 and molecular weight 218.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Formyl-4-(trifluoromethyl)benzoic acid (C9H5F3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2-Formyl-4-(trifluoromethyl)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5F3O3 |
| Molecular Weight | 218.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
Related Formyl Standards
- 4-Formyl-3-(trifluoromethyl)benzoic acid (CAS 1289083-41-5)
- 4-Formyl-2-(trifluoromethyl)benzoic acid (CAS 1289087-72-4)
- 2-Formyl-6-(trifluoromethyl)benzoic acid (CAS 1289156-92-8)
- 5-Formyl-2-(trifluoromethyl)benzoic acid (CAS 1289194-83-7)
- 2-Formyl-5-(trifluoromethyl)benzoic acid (CAS 13055-64-6)
- 3-Formyl-5-(trifluoromethyl)benzoic acid (CAS 604001-03-8)
- Methyl 3-Formyl-7-methyl-1H-indazole-4-carboxylate (CAS 1352395-25-5)
- Ethyl 3-formyl-1H-indazole-4-carboxylate (CAS 1416374-84-9)
Recommended Standards
- 2-Bromo-3-(homopiperidinyl)prop-1-ene (CAS 656797-88-5)
- 2-Hydroxy-4-(2,2,2-trifluoroacetyl)benzaldehyde (CAS 2231673-59-7)
- 2-(2,2,2-Trifluoroacetyl)benzoic acid (CAS 203124-56-5)
- 2-Oxo-2-(2-(trifluoromethyl)phenyl)acetic acid (CAS 467435-08-1)
- 8-(Chloromethyl)quinoline hydrochloride (CAS 2055119-01-0)
- Ebastine N-Oxide (CAS 1256285-71-8)
- 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol (CAS 1346526-26-8)
- Ramelteon Impurity 20 (CAS 1092507-02-2)
- 1-((1-Methyl-1H-pyrrol-2-yl)methyl)azepane (CAS 177721-86-7)
- 3-Bromo-2-(trifluoromethyl)pyridine-4-methanol (CAS 1227576-82-0)
- 2-(Difluoromethyl)-3-hydroxypyridine-4-acetonitrile (CAS 1806776-70-4)
- N-(2-Fluoro-5-nitrophenyl)acetamide (CAS 454-07-9)
- 5-(Aminomethyl)-4-(propan-2-yl)-4h-1,2,4-triazole-3-thiol hydrochloride (CAS 1258639-70-1)
- [D-Ser8]-Semaglutide A (CAS CATO-C4X-2226116)
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