Palbociclib Impurity 115 CAS 2399424-46-3
| CAS No. | 2399424-46-3 |
| Molecular Formula | C28H40N8O4 |
| Molecular Weight | 552.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 552.67 g/mol gives Palbociclib Impurity 115 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Palbociclib Impurity 115 (CAS 2399424-46-3, C28H40N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Palbociclib Impurity 115 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 552.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Palbociclib Impurity 115 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H40N8O4 |
| Molecular Weight | 552.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 8 |
Related Palbociclib Standards
- Palbociclib Impurity 94 (CAS CATO-C4X-112594)
- Palbociclib Impurity 33 (CAS 1651214-74-2)
- Palbociclib Impurity 89 (CAS 1974279-21-4)
- Palbociclib Impurity 141 (CAS CATO-C4X-1125141)
- Palbociclib Impurity 100 (CAS CATO-C4X-1125100)
- Palbociclib Impurity 200 (CAS 2204368-69-2)
- Palbociclib Impurity 40 (CAS CATO-C4X-112540)
- Palbociclib Impurity 116 (CAS CATO-C4X-1125116)
Recommended Standards
- N1,N4-bis(4-(N,N-dimethylsulfamoyl)phenyl)-1,4-diazepane-1,4-dicarboxamide (CAS 692733-06-5)
- Rabeprazole Impurity 8 (CAS 935260-92-7)
- Euphorbiasteroid (CAS 28649-59-4)
- Paliperidone Impurity 39 (CAS CATO-C4X-172439)
- Terbinafine lmpurity 27 (CAS 917-92-0)
- Atrasentan Impurity 3 (CAS CATO-C4X-33473)
- Baxdrostat Impurity 11 (CAS 3084664-97-8)
- 7-Hydroxy-1h-indole-3-carbaldehyde (CAS 148563-38-6)
- Ethoxysulfuron (CAS 126801-58-9)
- Piribedil Impurity 2 (CAS CATO-C4X-28132)
- 2-(Chloromethyl)-3-(difluoromethyl)-4-fluoropyridine-6-carboxaldehyde (CAS 1805535-56-1)
- Ethene, 1,1-dichloro-, homopolymer (CAS 9002-85-1)
- 7-(2,4-Dichlorophenyl)-5-hydroxybenzo[d][1,3]oxathiol-2-one (CAS 327078-58-0)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
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