Palbociclib Impurity 200 CAS 2204368-69-2
| CAS No. | 2204368-69-2 |
| Molecular Formula | C27H34ClN7O3 |
| Molecular Weight | 540.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Palbociclib Impurity 200 (CAS 2204368-69-2, C27H34ClN7O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Palbociclib Impurity 200 (C27H34ClN7O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 540.06 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C27H34ClN7O3 |
| Molecular Weight | 540.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
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- Palbociclib Impurity 16 (CAS CATO-C4X-112516)
- Palbociclib Impurity 76 (CAS 1941177-45-2)
- Palbociclib Sulfamic Acid (CAS CATO-C4X-112536)
- Palbociclib Impurity 115 (CAS 2399424-46-3)
Recommended Standards
- 4-((4-(4-Chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl)oxy)-1-(4-fluorophenyl)butan-1-one (CAS CATO-C3D-3484)
- Cyclopentyl 4-(2-chloro-6-fluorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 333308-80-8)
- N-(2-Chloro-4,6-dimethylphenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 476485-61-7)
- Encorafenib Impurity 2 (CAS 1269440-29-0)
- Linaclotide impurity 37 (CAS CATO-C4X-210637)
- Allisartan Isoproxil Impurity 2 (CAS CATO-C4X-32172)
- Tepotinib impurity 22 (CAS 1369761-19-2)
- 2,4,6-Tris[4-(1H-imidazol-1-yl)-phenyl]-1,3,5-triazine (CAS 1009564-95-7)
- (1Z,3Z)-1,3-Bis[[(4S)-4,5-dihydro-4-isopropyl-2-oxazolyl]methylene]-2,3-dihydro-1H-isoindole (CAS 1361563-40-7)
- Potassium Trifluoroacetate (CAS 2923-16-2)
- (E)-3-(5-Nitrocyclohex-1-en-1-yl)acrylic acid (CAS 899809-64-4)
- (5E)-4-(4-Methoxyphenyl)-5-{[(4-methylphenyl)methoxy]imino}-2-(1H-pyrrol-1-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (CAS 860649-69-0)
- 4-Aminoquinoline-7-carbonitrile (CAS 1253790-96-3)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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