Baricitinib Impurity N16 CAS 2402776-80-9
| CAS No. | 2402776-80-9 |
| Molecular Formula | C17H20N6O4S |
| Molecular Weight | 404.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Baricitinib Impurity N16.
CATO supplies Baricitinib Impurity N16 (CAS 2402776-80-9), a pharmacopoeial impurity reference standard (molecular formula C17H20N6O4S, MW 404.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C17H20N6O4S, Baricitinib Impurity N16 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 404.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H20N6O4S |
| Molecular Weight | 404.44 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Baricitinib Standards
- Baricitinib Impurity 123 (CAS CATO-C4X-2260123)
- Baricitinib Impurity 105 (CAS CATO-C4X-2260105)
- Baricitinib Impurity 17 (CAS 1187595-89-6)
- Baricitinib Impurity 81 (CAS CATO-C4X-226081)
- Baricitinib Impurity 136 (CAS CATO-C4X-2260136)
- Baricitinib Impurity 111 (CAS CATO-C4X-2260111)
- Baricitinib Impurity 47 (CAS CATO-C4X-226047)
- Baricitinib Impurity 50 (CAS 1187594-35-9)
Recommended Standards
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- 4,7-Dichloroindole-3-acetic Acid (CAS 63352-96-5)
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Why CATO?
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