Baricitinib Impurity 111 CAS CATO-C4X-2260111
| CAS No. | CATO-C4X-2260111 |
| Molecular Formula | C16H20N6O5S |
| Molecular Weight | 408.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Baricitinib Impurity 111 (CAS CATO-C4X-2260111, C16H20N6O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Baricitinib Impurity 111 (C16H20N6O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 408.43 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Baricitinib Impurity 111 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20N6O5S |
| Molecular Weight | 408.43 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Baricitinib Standards
- Baricitinib Impurity 101 (CAS CATO-C4X-2260101)
- Baricitinib Impurity N16 (CAS 2402776-80-9)
- Baricitinib Impurity 123 (CAS CATO-C4X-2260123)
- Baricitinib Impurity 40 (CAS CATO-C4X-226040)
- Baricitinib Impurity 105 (CAS CATO-C4X-2260105)
- Baricitinib Impurity 17 (CAS 1187595-89-6)
- Baricitinib Impurity 81 (CAS CATO-C4X-226081)
- Baricitinib Impurity 136 (CAS CATO-C4X-2260136)
Recommended Standards
- Olaparib Impurity 16 (CAS 848136-41-4)
- Droperidol Impurity 19 (CAS CATO-C4X-276919)
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- Dufulin (CAS 882182-49-2)
- Cefpirome Impurity 23 (CAS CATO-C4X-120723)
- Diacerein Impurity 8 (CAS 6030-60-0)
- Hydrochlorothiazide Impurity 19 (CAS 79271-56-0)
- Chrysene (CAS 218-01-9)
- Isopropyl 5-bromopyrimidine-4-carboxylate (CAS 1370725-01-1)
- 4-Cyclopropoxy-2-isopropoxy-N-methylpyridin-3-amine (CAS 1243349-66-7)
- 4-Bromo-2-(((2,3,4-trifluorophenyl)amino)methyl)phenol (CAS 868256-50-2)
- Methyl undec-2-ynoate (CAS 10522-18-6)
- 1-[5-(4-Chloro-3-fluorophenyl)-2-thienyl]ethanone (CAS 893735-24-5)
- [Plus-β-Ala28]-Semaglutide (CAS CATO-C4X-2226221)
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