阿法替尼杂质28 CAS 2414260-31-2
| CAS No. | 2414260-31-2 |
| Molecular Formula | C26H32ClFN6O3 |
| Molecular Weight | 531.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
阿法替尼杂质28 (CAS 2414260-31-2) is a certified pharmaceutical impurity reference standard with the molecular formula C26H32ClFN6O3 and a molecular weight of 531.02 g/mol.
The molecular framework of 阿法替尼杂质28 (C26H32ClFN6O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H32ClFN6O3 |
| Molecular Weight | 531.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Recommended Standards
- (S)-tert-Butyl 4-(7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate (CAS 2252403-84-0)
- Afatinib Impurity 26 (CAS CATO-C4X-100626)
- Ibrutinib Impurity 27 (CAS CATO-C4X-106427)
- 2-{2-[4-(3-Benzyloxy-phenylsulfanyl)-2-chloro-phenyl]-ethyl}-2-fluoro-malonic acid diethyl ester (CAS 1023648-24-9)
- Dl-Lysine Acetylsalicylate EP Impurity B (CAS 13393-44-7（free base）)
- Pemetrexed Impurity 52 (CAS CATO-C4X-172652)
- Hydrocortisone EP Impurity L (CAS 641-77-0)
- 2-Ethyl-1-benzofuran-3-carbaldehyde (CAS 10035-41-3)
- 2-(1-Methylethoxy)-4-pyridinamine (CAS 1247371-36-3)
- Ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxylate (CAS 108993-84-6)
- 3-Ethynyl-4-fluorobenzoic acid (CAS 1864748-42-4)
- 3-[(4-fluorophenoxy)methyl]-4-methoxybenzaldehyde (CAS 329222-88-0)
- ((3R,4R)-4-(difluoromethyl)pyrrolidin-3-yl)methanol hydrochloride (CAS 2306247-23-2)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
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