Hydrocortisone EP Impurity L CAS 641-77-0
| CAS No. | 641-77-0 |
| Molecular Formula | C21H30O4 |
| Molecular Weight | 346.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Hydrocortisone EP Impurity L (C21H30O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Hydrocortisone EP Impurity L (CAS 641-77-0), a pharmacopoeial impurity reference standard (molecular formula C21H30O4, MW 346.46 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Hydrocortisone EP Impurity L meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H30O4 |
| Molecular Weight | 346.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Hydrocortisone Standards
- Hydrocortisone EP Impurity F (CAS 152-58-9)
- Hydrocortisone Impurity (CAS 20287-97-2)
- Hydrocortisone Impurity 31 (CAS 10184-70-0)
- Hydrocortisone (E)-17-Deoxyaldehyde Derivative (CAS 105562-12-7)
- Hydrocortisone (Z)-17-Deoxyaldehyde Derivative (CAS 105562-13-8)
- Hydrocortisone Impurity 68 (CAS 3103-16-0)
- Hydrocortisone (9beta,11beta)-Epoxide (CAS 10072-97-6)
- Hydrocortisone EP Impurity A (CAS 50-24-8)
Recommended Standards
- Rocuronium Impurity 57 (CAS CATO-C4X-124257)
- Rocuronium Impurity 54 (CAS CATO-C4X-124254)
- Algestone (CAS 595-77-7)
- Rocuronium Impurity 10 (CAS 50588-22-2)
- Dalbavancin Impurity 54 (CAS CATO-C4X-160254)
- Lamotrigine impurity 20 (CAS 136565-76-9)
- Tofacitinib Impurity 151 (CAS 1548270-19-4)
- (R)-6-Bromo-1-methylisoindoline (CAS 1388854-85-0)
- MMF-TTEG-MMF (CAS 1817769-42-8)
- 1,3-Dimethyl-2-Nitrosobenzene (Mixture of Monomer and Dimer) (CAS 19519-71-2)
- Benzyl ((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-3-yl)(methyl)carbamate (CAS 1401666-29-2)
- 4-Chloro-6-methoxy-1H-pyrazolo[3,4-d]pyrimidine (CAS 1060816-54-7)
- 1-Cyclohexyl-2,2-Difluoro-2-(Methylsulfanyl)Ethanone (CAS 170654-39-4)
- [Nva12]-Tirzepatide (CAS CATO-C4X-324042)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com