5-Chloro-3-phenyl-1,2,4-thiadiazole CAS 24255-23-0
| CAS No. | 24255-23-0 |
| Molecular Formula | C8H5ClN2S |
| Molecular Weight | 196.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-3-phenyl-1,2,4-thiadiazole.
5-Chloro-3-phenyl-1,2,4-thiadiazole (CAS 24255-23-0) is a high-purity analytical reference standard with the molecular formula C8H5ClN2S and a molecular weight of 196.66 g/mol.
The molecular framework of 5-Chloro-3-phenyl-1,2,4-thiadiazole (C8H5ClN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClN2S |
| Molecular Weight | 196.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
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- 4-Chloro-2-(thiophen-3-yl)pyrimidine (CAS 1156237-51-2)
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Recommended Standards
- 4-Chloro-6-(thiophen-3-yl)pyrimidine (CAS 898546-96-8)
- 5-Chloro-4-phenyl-1,2,3-thiadiazole (CAS 53646-00-7)
- 4-Chloro-6-(thiophen-2-yl)pyrimidine (CAS 374554-75-3)
- 7-Chloro-1,6-naphthyridine-2(1H)-thione (CAS 2639539-20-9)
- 2-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethyl)-2,3-dihydro-1H-isoindole-1,3-dione (CAS 338761-86-7)
- 1H,1H,2H,3H,3H-Perfluorononane-1,2-diol (CAS 107650-06-6)
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- N'-(1-(Pyridin-2-yl)ethylidene)pyrrolidine-1-carbothiohydrazide (CAS 71555-26-5)
- Butylhydrazine Dihydrochloride (CAS 70629-61-7)
- 5-O-Desmethyl Donepezil-d5 (CAS 1189929-21-2)
- 8-(Benzyloxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (CAS 1032570-69-6)
- 4-(1-(tert-Butoxycarbonyl)-1H-pyrrol-2-yl)benzoic acid (CAS 669713-98-8)
- 1H-Benzimidazole-7-carbonitrile, 2-chloro-1-methyl- (CAS 1780878-01-4)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
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