Berberine Impurity 3 CAS 2435-73-6
| CAS No. | 2435-73-6 |
| Molecular Formula | C20H18NO5 |
| Molecular Weight | 352.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Berberine Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 352.36 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Berberine Impurity 3 (CAS 2435-73-6, C20H18NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Berberine Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H18NO5 |
| Molecular Weight | 352.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 34 (CAS CATO-C4X-219934)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 27 (CAS CATO-C4X-219927)
- Berberine Impurity 28 (CAS CATO-C4X-219928)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 30 (CAS 2648606-63-5)
- Berberine Impurity 7 (CAS 65615-23-8)
Recommended Standards
- Acotiamide Impurity 24 (CAS 185106-05-2)
- n-[4-(5-carbamoyl-1h-pyrrol-3-yl)-1,3-thiazol-2-yl]-1h-indazole-3-carboxamide (CAS 1061528-46-8)
- Acotiamide Impurity 18 (CAS CATO-C4X-111418)
- 3-((6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)thio)propanenitrile (CAS 148527-87-1)
- Prasugrel EP Impurity E (CAS 1056459-37-0)
- Plerixafor Impurity 33 DiHCl (CAS CATO-C4X-113333)
- Siponimod impurity 18 (CAS CATO-C4X-247218)
- 5-Cyclopropyl-1-(ethoxymethyl)-6-(phenylthio)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 136160-37-7)
- 5-Methyl-3-nitropicolinaldehyde (CAS 52381-07-4)
- 2-Bromo-5-fluoro-4-methylbenzaldehyde (CAS 916792-21-7)
- 2-Amino-9-(cis-6-(hydroxymethyl)-1,4-oxathian-2-yl)-1H-purin-6(9H)-one (CAS 132062-74-9)
- 4,4'-(E)-Diazene-1,2-diyldibenzoic acid (CAS 71987-42-3)
- 1-(5-Fluoropyrimidin-4-yl)ethan-1-one (CAS 1289559-75-6)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com