Berberine Impurity 28 CAS CATO-C4X-219928
| CAS No. | CATO-C4X-219928 |
| Molecular Formula | C22H20N2O4 |
| Molecular Weight | 376.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Berberine Impurity 28 (CAS CATO-C4X-219928), a pharmacopoeial impurity reference standard (molecular formula C22H20N2O4, MW 376.41 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Berberine Impurity 28 (C22H20N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 376.41 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H20N2O4 |
| Molecular Weight | 376.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 3 (CAS 2435-73-6)
- Berberine Impurity 34 (CAS CATO-C4X-219934)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 27 (CAS CATO-C4X-219927)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 30 (CAS 2648606-63-5)
- Berberine Impurity 7 (CAS 65615-23-8)
Recommended Standards
- Irinotecan Impurity 23 (CAS 1217633-65-2)
- Finerenone Impurity 12 (CAS 2084136-51-4)
- Irinotecan EP Impurity F (CAS 78287-27-1)
- Abemaciclib Impurity 184 (CAS CATO-C4X-2937184)
- Cholecalciferol EP Impurity E (CAS 17592-07-3)
- Tipiracil Impurity 7 (CAS 6674-22-2)
- Acebutolol EP Impurity J (CAS 57898-79-0)
- Ethyl 3-(3,4-dichlorophenoxy)propanoate (CAS 91090-73-2)
- Fumaramide (CAS 627-64-5)
- 2-(Difluoromethyl)-5-fluoro-3-iodopyridine-4-methanol (CAS 1805049-78-8)
- Nifuratel Impurity 4 (CAS 1445990-09-9)
- N1,N4-Bis(4-Butylphenyl)-1,4-Benzenediamine (CAS 372200-88-9)
- 3-(5-(2,3-Dichlorophenyl)furan-2-yl)-1-(4-methoxyphenyl)prop-2-en-1-one (CAS 304896-55-7)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com