Linagliptin Impurity 83 CAS 2436762-89-7
| CAS No. | 2436762-89-7 |
| Molecular Formula | C14H13BrN4O2 |
| Molecular Weight | 349.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Linagliptin Impurity 83.
As a process- or degradation-related impurity, Linagliptin Impurity 83 (CAS 2436762-89-7, C14H13BrN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Linagliptin Impurity 83 (C14H13BrN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 349.18 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Linagliptin Impurity 83 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13BrN4O2 |
| Molecular Weight | 349.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Linagliptin Standards
- Linagliptin Impurity 1 (CAS CATO-C4X-11011)
- Linagliptin impurity 99 (CAS CATO-C4X-110199)
- Linagliptin impurity 97 (CAS CATO-C4X-110197)
- Linagliptin impurity 151 (CAS CATO-C4X-1101151)
- Linagliptin Impurity 26 (CAS CATO-C4X-110126)
- Linagliptin Impurity 3 (CAS CATO-C4X-11013)
- Linagliptin Impurity 29 (CAS 1911621-52-7)
- Linagliptin impurity 136 (CAS CATO-C4X-1101136)
Recommended Standards
- 4-Iodo-N-(2-methylbut-3-yn-2-yl)benzenesulfonamide (CAS 1009101-88-5)
- N-(4-bromophenyl)-2-(2-nitroethyl)benzamide (CAS 343372-62-3)
- N-(4-Cyanopyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 1418307-35-3)
- 7-Benzyl-8-bromo-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (CAS 70404-23-8)
- Theophylline EP Impurity D (CAS 6736-40-9)
- Noradrenalone EP Impurity B (CAS 499-61-6)
- Rifamycin Impurity 15 (CAS CATO-C4X-200413)
- (3-(3,4-Dichlorophenyl)-2-oxooxazolidin-5-yl)methyl carbamate (CAS 42902-48-7)
- N-(1-(1H-Benzo[d][1,2,3]triazol-1-yl)butyl)benzamide (CAS 117067-47-7)
- 143230-42-6 2-(2-(6-Chloro-pyrimidin-4-yloxy)-phenyl)-3,3-dimethoxy-propionic acid methyl ester EC 604-340-6 (CAS 143230-42-6)
- Ethyl 4-(4,4-dimethylpiperidin-1-yl)benzoate (CAS 406233-25-8)
- 2-(Buta-1,3-dien-1-yl)-1,3,5-trimethylbenzene (CAS 5732-00-3)
- 5-Chloro-1,3-dimethyl-1,2-dihydropyrimido[5,4-e][1,2,4]triazine (CAS 91983-24-3)
- Peptide 433 (CAS CATO-CPTD788433)
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