N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide CAS 243844-35-1
| CAS No. | 243844-35-1 |
| Molecular Formula | C14H14ClNO2S |
| Molecular Weight | 295.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide (CAS 243844-35-1), a certified reference material (molecular formula C14H14ClNO2S, MW 295.78 g/mol) for analytical method development and quality control.
The molecular framework of N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide (C14H14ClNO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14ClNO2S |
| Molecular Weight | 295.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
- N-(5-chloro-2-methylphenyl)-4-methylbenzenesulfonamide (CAS 55816-01-8)
- Propyl 2-amino-4-(2-chlorophenyl)thiophene-3-carboxylate (CAS 351158-61-7)
- N-(4-Chlorophenyl)-2,5-dimethylbenzenesulfonamide (CAS 71796-20-8)
- Propyl 2-amino-4-(4-chlorophenyl)thiophene-3-carboxylate (CAS 350997-20-5)
- Propylenebis(dithiocarbamic) acid (CAS 35449-52-6)
- 2,4-Dichloro-5-methylfuro[2,3-d]pyrimidine (CAS 1160994-79-5)
- Chloro 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-glucopyranose (CAS 3068-34-6)
- Dipropyl malonate (CAS 1117-19-7)
- Methyl 2-(3-bromophenyl)acetate (CAS 150529-73-0)
- Tasidotin (CAS 192658-64-3)
- 2,5-Dioxopyrrolidin-1-yl 3-(2-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)propanoate (CAS 1260092-31-6)
- N-[1-(5-Amino-1,3,4-thiadiazol-2-yl)-2-methylpropyl]benzamide (CAS 1291486-37-7)
- 2-(3-fluoro-4-methoxyphenyl)cyclohexan-1-one (CAS 1311317-72-2)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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