3-Chloro-N-(6-(2,4-difluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide CAS 243963-11-3
| CAS No. | 243963-11-3 |
| Molecular Formula | C16H15ClF2N2O2 |
| Molecular Weight | 340.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-N-(6-(2,4-difluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide.
3-Chloro-N-(6-(2,4-difluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide (CAS 243963-11-3), molecular formula C16H15ClF2N2O2 and molecular weight 340.75 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chloro-N-(6-(2,4-difluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide (C16H15ClF2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chloro-N-(6-(2,4-difluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H15ClF2N2O2 |
| Molecular Weight | 340.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- (6-Chloro-4-trifluoromethyl-pyridin-2-ylsulfanyl)-acetic acid [1-dimethylamino-meth-(E)-ylidene]-hydrazide (CAS 1858264-43-3)
- 2-(2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)propanoyl)-N-methylhydrazine-1-carbothioamide (CAS 339010-58-1)
- 3-Chloro-N-(2-(2,4-difluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide (CAS 243963-32-8)
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Recommended Standards
- 5-(2-(4-Chlorophenyl)-2-oxoethylidene)-2-imino-3-(o-tolyl)oxazolidin-4-one (CAS 122975-87-5)
- 2-[(2-Chlorophenyl)sulfanyl]-3-(trifluoromethyl)quinoxaline (CAS 338773-65-2)
- 2-((4-Chlorophenyl)thio)-3-(trifluoromethyl)quinoxaline (CAS 321433-72-1)
- N-Benzyl-6-chloro-5-nitro-2-phenylpyrimidin-4-amine (CAS 192631-76-8)
- 6-Bromo-7-methoxy-2,3-dihydro-1H-inden-1-one (CAS 1273599-65-7)
- 4-Bromo-3-methyl-1,2-thiazole-5-carboxylic acid (CAS 89284-01-5)
- Propargyl-PEG7-NHS ester (CAS 2093152-77-1)
- (3-Cyano-5-ethynylphenyl)boronic acid (CAS 1189363-70-9)
- Benzyl (4-(benzyloxy)-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycinate (CAS 808118-43-6)
- Ammonium perfluorooctanesulfonate (CAS 29081-56-9)
- 2-(3-(2-Methoxyphenyl)-6-oxopyridazin-1(6H)-yl)acetic acid (CAS 1286724-41-1)
- (3-Chloro-4-methoxypyridin-2-yl)methanamine (CAS 1427384-35-7)
- Ethyl 2-amino-4-isopropylthiazole-5-carboxylate (CAS 72850-76-1)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
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