N1-[2-(2-fluorophenoxy)-3-pyridyl]-3-chloro-2,2-dimethylpropanamide CAS 243963-33-9
| CAS No. | 243963-33-9 |
| Molecular Formula | C16H16ClFN2O2 |
| Molecular Weight | 322.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 322.76 g/mol gives N1-[2-(2-fluorophenoxy)-3-pyridyl]-3-chloro-2,2-dimethylpropanamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N1-[2-(2-fluorophenoxy)-3-pyridyl]-3-chloro-2,2-dimethylpropanamide (CAS 243963-33-9) is a high-purity analytical reference standard with the molecular formula C16H16ClFN2O2 and a molecular weight of 322.76 g/mol.
N1-[2-(2-fluorophenoxy)-3-pyridyl]-3-chloro-2,2-dimethylpropanamide (C16H16ClFN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16ClFN2O2 |
| Molecular Weight | 322.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- 3-Chloro-N-(6-(4-fluorophenoxy)pyridin-3-yl)-2,2-dimethylpropanamide (CAS 243963-12-4)
- N-(4-Chlorophenyl)-3-methyl[1,2,4]triazolo-[4,3-a]pyridine-8-sulfonamide (CAS 1638612-49-3)
- 4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidin-5-one (CAS 29303-21-7)
- 2-(4-Nitrophenoxy)quinoxaline (CAS 154325-17-4)
- N1-(2,2-bis(ethylthio)acetyl)-N2-phenyloxalamide (CAS 338975-26-1)
- (R)-2-Aminobutane-1,4-diol (CAS 80572-06-1)
- Benzyl (R)-2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate (CAS 2679928-69-7)
- 1-(3-Fluorophenyl)-2-(oxetan-3-ylthio)ethan-1-one (CAS 1538495-13-4)
- Methyl 3-chloro-5H,6H,7H-cyclopenta[c]pyridazine-4-carboxylate (CAS 2091710-34-6)
- 4-(prop-2-yn-1-yl)thiomorpholine-3,5-dione (CAS 1565520-88-8)
- Trichloromethyl Isocyanate (CAS 30121-98-3)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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