Palbociclib Impurity 68 CAS 2444702-87-6
| CAS No. | 2444702-87-6 |
| Molecular Formula | C14H21BrN4 |
| Molecular Weight | 325.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Palbociclib Impurity 68 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Palbociclib Impurity 68 (CAS 2444702-87-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H21BrN4 and a molecular weight of 325.25 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution, Palbociclib Impurity 68 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 325.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Palbociclib Impurity 68 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H21BrN4 |
| Molecular Weight | 325.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Palbociclib Standards
- Palbociclib Impurity 190 (CAS CATO-C4X-1125190)
- Palbociclib Impurity 53 (CAS 1922954-32-2)
- Palbociclib Impurity 108 (CAS 1311611-88-7)
- Palbociclib Impurity 69 (CAS 6163-63-9)
- Palbociclib Impurity 98 (CAS 2340184-77-0)
- Palbociclib Impurity 45 (CAS 1439-36-7)
- Palbociclib Impurity 171 (CAS CATO-C4X-1125171)
- Palbociclib Impurity 156 (CAS CATO-C4X-1125156)
Recommended Standards
- tert-Butyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-carbamate 4-boc-aminophenylboronic acid, pinacol ester 4-(Boc-amino)benzeneboronic acid pinacol ester (4-boc-aminophenyl)boronic acid, pinacol ester t-butyl-n-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 4-(tert-Butoxycarbonylamino)phenylboronic acid pinacol ester tert-butyl-n-[4-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)phenyl]carbamate tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate 4-(n-boc-amino)phenylboronic acid pinacol ester tert-butyl-n-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 4-butoxycarbonylaminophenylboronic acid, pinacol ester 4-tert-butoxycarbonylaminophenylboronic acid, pinacol 4-(boc-amino)phenylboronic acid pinacol cyclic ester 4-(tert-butoxycarbonyl)aminophenylboronic acid, pinacol ester t-butyl n-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)phenyl]carbamate (4-Boc-aminophenyl)boronic acid pinacol ester 330793-01-6 (CAS 330793-01-6)
- Atogepant Impurity 15 (CAS CATO-C4X-328515)
- Tert-butyl 3-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)piperidine-1-carboxylate (CAS 2365173-87-9)
- 6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridine (CAS 1186310-73-5)
- Bucladesine Impurity 1 (CAS 55443-13-5)
- Amlodipine impurity 126 (CAS CATO-C4X-1095126)
- Dexmedetomidine Impurity 21 (CAS 2514763-84-7)
- 4-((4-(tert-Butyl)phenyl)sulfonamido)benzoic acid (CAS 708996-17-2)
- 2-((1-((Benzyloxy)carbonyl)piperidin-4-yl)(cyclopropyl)amino)acetic acid (CAS 1353982-90-7)
- (2E)-3-(Dimethylamino)-1-[4-(phenylsulfanyl)phenyl]prop-2-en-1-one (CAS 321432-58-0)
- 5-(5-Methylfuran-2-yl)isoxazol-3-amine (CAS 1514588-97-6)
- Ibuprofen Impurity 45 (CAS CATO-C4X-108245)
- 4'-Bromo-3'-methoxy-[1,1'-biphenyl]-3-carboxylic acid (CAS 1215206-10-2)
- Acetyl decapeptide-3 (CAS 935288-50-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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