Ethyl 8-bromo-2-(difluoromethyl)-6-methylimidazo[1,2-a]pyridine-3-carboxylate CAS 2451256-44-1
| CAS No. | 2451256-44-1 |
| Molecular Formula | C12H11BrF2N2O2 |
| Molecular Weight | 333.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 8-bromo-2-(difluoromethyl)-6-methylimidazo[1,2-a]pyridine-3-carboxylate (CAS 2451256-44-1), molecular formula C12H11BrF2N2O2 and molecular weight 333.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 8-bromo-2-(difluoromethyl)-6-methylimidazo[1,2-a]pyridine-3-carboxylate (C12H11BrF2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11BrF2N2O2 |
| Molecular Weight | 333.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
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- Ethyl 6-bromo-2-(difluoromethyl)-8-methylimidazo[1,2-a]pyridine-3-carboxylate (CAS 2451256-39-4)
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Recommended Standards
- 2-(2,4-Difluorophenoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1105663-76-0)
- DImethyl 2,2'-((2-bromo-1,4-phenylene)bis(oxy))diacetate (CAS 84794-82-1)
- 4-Hydrazino-N-(4-iodophenyl)-4-oxobutanamide (CAS 443863-27-2)
- (1-(Tert-butoxycarbonyl)-4-(ethoxycarbonyl)-1H-indol-2-yl)boronic acid (CAS 1150114-37-6)
- tert-Butyl 5-methoxy-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (CAS 928653-83-2)
- 7-Hydroxy-PIPAT (CAS 159559-71-4)
- Pyrazole (CAS 288-13-1)
- 3-(4-Bromophenyl)-1-phenyl-1h-pyrazole-4-carbaldehyde (CAS 36640-41-2)
- 4-Amino-5-bromo-2-fluorophenol (CAS 1805106-67-5)
- 5-(2-Bromo-4-fluorophenyl)furan-2-carbaldehyde (CAS 944894-44-4)
- 5-Bromoindolizine-2-carbonitrile (CAS 1474057-87-8)
- 2,5-Dimethyl-N-(1h-pyrazol-4-yl)furan-3-carboxamide (CAS 1157112-10-1)
- N-(2-Hydroxyethyl)carbamodithioic Acid Methyl Ester (CAS 56158-48-6)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
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