Ethyl 6,8-dichloro-2-(difluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate CAS 2451256-45-2
| CAS No. | 2451256-45-2 |
| Molecular Formula | C11H8Cl2F2N2O2 |
| Molecular Weight | 309.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 309.10 g/mol gives Ethyl 6,8-dichloro-2-(difluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ethyl 6,8-dichloro-2-(difluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate (CAS 2451256-45-2), molecular formula C11H8Cl2F2N2O2 and molecular weight 309.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 6,8-dichloro-2-(difluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate (C11H8Cl2F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Ethyl 6,8-dichloro-2-(difluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8Cl2F2N2O2 |
| Molecular Weight | 309.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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- 1-Methyldecahydro-1,5-naphthyridine (CAS 933741-91-4)
- 3,5-Dimethyl-4-p-tolylsulfanyl-1h-pyrazole (CAS 385405-23-2)
- 2,2-Difluoro-3-hydroxy-3-(3-pyridyl)propanoic Acid (CAS 887354-54-3)
- 2-Chloro-3-fluoropyridine 1-oxide (CAS 85386-94-3)
- Ilaprazole Impurity 16 (CAS CATO-C4X-113016)
- 1-Benzyl-1,6-diazaspiro[3.3]heptane hemioxalate (CAS 1223573-43-0)
- Lemborexant impurity 19 (CAS 2541020-19-1)
- 4-[(9-Anthracenylmethylene)amino]-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one (CAS 303019-69-4)
- (R)-2-Methyl-1-((R)-1-phenylethyl)piperidin-4-one (CAS 1421254-70-7)
- (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) trifluoroacetate salt (CAS 2022956-55-2)
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