Empagliflozin Impurity 144 CAS 2452301-32-3
| CAS No. | 2452301-32-3 |
| Molecular Formula | C23H25ClO7 |
| Molecular Weight | 448.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Empagliflozin Impurity 144 (CAS 2452301-32-3) is a certified pharmaceutical impurity reference standard with the molecular formula C23H25ClO7 and a molecular weight of 448.89 g/mol.
Based on its molecular formula C23H25ClO7, Empagliflozin Impurity 144 contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 448.89 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H25ClO7 |
| Molecular Weight | 448.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 120 (CAS CATO-C4X-1065120)
- Empagliflozin Impurity 150 (CAS CATO-C4X-1065150)
- Empagliflozin Impurity 217 (CAS CATO-C4X-1065217)
- Empagliflozin impurity 02 (CAS 1620758-31-7&1620758-32-8)
- Empagliflozin (CAS 864070-44-0)
- Empagliflozin Impurity 1 (CAS 864070-43-9)
- Empagliflozin Impurity 10 (CAS 2452301-42-5)
- Empagliflozin Impurity 117 (CAS CATO-C4X-1065117)
Recommended Standards
- (13s,14s,17s)-13-ethyl-3-methoxy-7,11,12,13,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-17-ol(non-preferred name) 7790-39-8 KST-1A8207 (CAS 7790-39-8)
- Pyrapropoyne (CAS 1803108-03-3)
- Bis(2,4,6-Trichlorophenyl)Oxalate (CAS 1165-91-9)
- Gefitinib Impurity 39 (CAS CATO-C4X-111739)
- Etoricoxib Impurity 89 (CAS CATO-C4X-108089)
- Lenvatinib Impurity 98 (CAS CATO-C4X-114098)
- Latamoxef impurity 46 (CAS CATO-C4X-179846)
- 4-Benzyl 1-(tert-butyl) 2-formyl-1,4-piperazinedicarboxylate (CAS 1036397-56-4)
- 3-Propyl-3H-purin-6(7H)-one (CAS 327036-87-3)
- (1-Hydroxycyclopropyl)(piperazin-1-yl)methanone (CAS 1213262-96-4)
- 1-(4-(Difluoromethyl)benzo[d]oxazol-2-yl)ethanone (CAS 1804213-66-8)
- (1-(4-Chloro-5-methylpyrimidin-2-yl)piperidin-3-yl)methanamine hydrochloride (CAS 1420828-25-6)
- 3-(3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)propanoic acid (CAS 108446-79-3)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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