Empagliflozin Impurity 1 CAS 864070-43-9
| CAS No. | 864070-43-9 |
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Empagliflozin Impurity 1 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Empagliflozin Impurity 1 (CAS 864070-43-9) is a certified pharmaceutical impurity reference standard with the molecular formula C23H27ClO7 and a molecular weight of 450.91 g/mol.
The molecular framework of Empagliflozin Impurity 1 (C23H27ClO7) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Empagliflozin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 02 (CAS 1620758-31-7&1620758-32-8)
- Empagliflozin (CAS 864070-44-0)
- Empagliflozin Impurity 10 (CAS 2452301-42-5)
- Empagliflozin Impurity 117 (CAS CATO-C4X-1065117)
- Empagliflozin Impurity 118 (CAS CATO-C4X-1065118)
- Empagliflozin Impurity 13 (CAS CATO-C4X-106513)
- Empagliflozin Impurity 131 (CAS CATO-C4X-1065131)
- Empagliflozin Impurity 137 (CAS CATO-C4X-1065137)
Recommended Standards
- Ethyl 3-[(E)-N'-[(2-chloro-6-fluorophenyl)methoxy]imidamido]-4-(dimethylamino)thieno[2,3-b]pyridine-2-carboxylate (CAS 341967-25-7)
- (E)-[(2-{[(4-chlorophenyl)methyl]sulfanyl}quinolin-3-yl)methylidene]amino 4-fluorobenzoate (CAS 478065-89-3)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-4-[3-(trifluoromethyl)phenoxy]-5,6,7,8-tetrahydroquinazoline (CAS 339019-04-4)
- (6aR,9aS)-3-Chloro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one (CAS 1351961-58-4)
- Empagliflozin Impurity 294 (CAS CATO-C4X-1065294)
- Apixaban impurity 01 (CAS 501-58-6)
- Dapagliflozin Impurity 63 (CAS 2768435-31-8)
- N-(sec-Butyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-((1-(p-tolyl)-1H-benzo[d]imidazol-2-yl)thio)acetamide (CAS 854026-22-5)
- (5-Chloro-2,4-dimethylphenyl)boronic acid (CAS 854662-82-1)
- 5-Cyclopropyl-1-methyl-1H-pyrazole-3-carbaldehyde (CAS 1554583-20-8)
- 2-Ethylbutyl 4-(6-bromobenzo[d][1,3]dioxol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 300360-05-8)
- 1,3-Dimethyl-5-nitro-1h-pyrazole (CAS 1170783-25-1)
- 2-Naphthol-13C10 (CAS 1346600-24-5)
- Hexapeptide-11 (CAS 161258-30-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com