(S)-(4,4-Difluoro-1-isopropylpyrrolidin-2-yl)methanol CAS 2454490-41-4
| CAS No. | 2454490-41-4 |
| Molecular Formula | C8H15F2NO |
| Molecular Weight | 179.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(S)-(4,4-Difluoro-1-isopropylpyrrolidin-2-yl)methanol (CAS 2454490-41-4) is a high-purity analytical reference standard with the molecular formula C8H15F2NO and a molecular weight of 179.21 g/mol.
The molecular framework of (S)-(4,4-Difluoro-1-isopropylpyrrolidin-2-yl)methanol (C8H15F2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H15F2NO |
| Molecular Weight | 179.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 2-Amino-1-(4,4-difluorocyclohexyl)ethan-1-ol (CAS 2090451-61-7)
- 2-Fluoro-5-(thiophen-3-yl)pyridine (CAS 837376-41-7)
- 5-Fluoroquinoline-8-thiol (CAS 1892-91-7)
- 1-(4-Chlorobenzenesulfonyl)-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine (CAS 1025724-67-7)
- 3-Amino-3-(4-cyanophenyl)propanoic acid (CAS 80971-95-5)
- N-(3-Chloro-4-fluorophenyl)-2-fluorobenzamide (CAS 349128-65-0)
- 4-((1R,2R,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazole-2,5-dione (CAS 419565-13-2)
- 3-((4-aminophenyl)sulfonyl)aniline (CAS 34262-32-3)
- 3-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylic acid (CAS 1535990-71-6)
- (4-(Phenylethynyl)phenyl)boronic acid (CAS 702699-63-6)
- N-(2-Oxo-2-((3-(2-oxopyrrolidin-1-yl)phenyl)amino)ethyl)-4-(2-oxopyrrolidin-1-yl)benzamide (CAS 924237-73-0)
- Ethyl 2-(2,2-dimethylpiperidin-4-yl)acetate hydrochloride (CAS 104094-97-5)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
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