1-bromo-8-chloro-3-(methoxymethoxy)naphthalene CAS 2454490-96-9
| CAS No. | 2454490-96-9 |
| Molecular Formula | C12H20BrClO2 |
| Molecular Weight | 311.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-bromo-8-chloro-3-(methoxymethoxy)naphthalene (CAS 2454490-96-9), molecular formula C12H20BrClO2 and molecular weight 311.64 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-bromo-8-chloro-3-(methoxymethoxy)naphthalene (C12H20BrClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-bromo-8-chloro-3-(methoxymethoxy)naphthalene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H20BrClO2 |
| Molecular Weight | 311.64 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl/Br-containing |
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Recommended Standards
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- 3-Nitro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (CAS 1000340-52-2)
- 1-[(1R)-1-Phenylethyl]-1H-imidazole-5-carboxylic acid-[4-[3-(trifluoromethyl)-3H-diazirin-3-yl]pheny (CAS 908024-18-0)
- N-methyl-N-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)methanesulfonamide (CAS 400074-00-2)
- (4-(1-(Hydroxymethyl)cyclopropyl)phenyl)boronic acid (CAS 1217501-10-4)
- Benzyl (10-hydroxydecyl)carbamate (CAS 96409-12-0)
- 1-(2,2-Diethoxyethyl)-2,4-difluorobenzene (CAS 1443342-21-9)
- 5,6,7,8-Tetrahydro-2,7-naphthyridin-3-amine (CAS 2706240-38-0)
- 2-[4-(3,5-dimethyl-1h-pyrazol-1-yl)phenyl]acetonitrile (CAS 956986-59-7)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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