1-Acetyl-5-fluoro-3-methylpyrrolidin-2-one CAS 246181-65-7
| CAS No. | 246181-65-7 |
| Molecular Formula | C7H10FNO2 |
| Molecular Weight | 159.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Acetyl-5-fluoro-3-methylpyrrolidin-2-one.
1-Acetyl-5-fluoro-3-methylpyrrolidin-2-one (CAS 246181-65-7) is a high-purity analytical reference standard with the molecular formula C7H10FNO2 and a molecular weight of 159.16 g/mol.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 1-Acetyl-5-fluoro-3-methylpyrrolidin-2-one is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 159.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Acetyl-5-fluoro-3-methylpyrrolidin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H10FNO2 |
| Molecular Weight | 159.16 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Acetyl Standards
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Recommended Standards
- (S)-2-Amino-2-(3-fluorobicyclo[1.1.1]pentan-1-yl)acetic acid (CAS 2020350-39-2)
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- (R)-2-amino-2-(3-fluorobicyclo[1.1.1]Pentan-1-yl)acetic acid (CAS 2198170-51-1)
- 2-(Hydroxymethyl)-5-nitrothiophene (CAS 20898-85-5)
- 3-(9,9-Dimethyl-9H-fluoren-2-yl)-7,8,9,10-tetraphenylfluoranthene (CAS 653591-68-5)
- FA-Gly-Abu-NH2 (M-1835.0050) (CAS 67607-48-1)
- 2-Cyano-N-(5-methoxybenzo[d]thiazol-2-yl)acetamide (CAS 1260942-40-2)
- 1-(Cyclohex-2-en-1-yl)quinazolin-4(1H)-one (CAS 28751-75-9)
- 2-(1-Ethoxyethyl)-4-methylpyrimidine-5-carboxylic acid (CAS 1342419-24-2)
- 2-((4-Ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxyphenyl)acetamide (CAS 578003-17-5)
- 2-(2-Bromobenzyl)-3-methylbutanoic acid (CAS 1249965-21-6)
- 1'-Methyl-4'-(3-nitrophenyl)-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione (CAS 1797898-37-3)
- 5-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1073338-95-0)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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