Salbutamol EP Impurity A HCl CAS 2468639-65-6
| CAS No. | 2468639-65-6 |
| Molecular Formula | C14H23NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 289.80 g/mol gives Salbutamol EP Impurity A HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Salbutamol EP Impurity A HCl (CAS 2468639-65-6, C14H23NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Salbutamol EP Impurity A HCl is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 289.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Salbutamol EP Impurity A HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H23NO3 HCl |
| Molecular Weight | 289.80 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Salbutamol Standards
- Salbutamol Impurity 130 (CAS 115061-55-7)
- Salbutamol Impurity 134 (CAS 115787-50-3)
- Salbutamol Impurity 55 (CAS 115787-52-5)
- Salbutamol Impurity 85 (CAS 115787-52-5（free base）)
- Salbutamol Impurity 87 (CAS 115787-53-6)
- Salbutamol-d3 (CAS 1219798-60-3)
- Salbutamol Impurity 75 (CAS 1221726-71-1)
- Salbutamol Impurity 146 (CAS 124658-76-0)
Recommended Standards
- Lubiprostone Impurity 28 (CAS CATO-C4X-113628)
- Ambroxol impurity 109 (CAS CATO-C4X-1085109)
- Ceritinib Impurity 86 (CAS /)
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- 1-Iodo-4-phenylbicyclo[2.2.2]octane (CAS 55044-15-0)
- 2-(2-Chloro-4-isopropylphenoxy)acetohydrazide (CAS 1555285-35-2)
- 1,3-Dithiane (CAS 505-23-7)
- 2-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 1378340-42-1)
- Osteoblast Activating Peptide (mouse, rat) (H-7262.0500) (CAS 1222950-80-2)
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