Carfilzomib Impurity 43 CAS 247068-85-5
| CAS No. | 247068-85-5 |
| Molecular Formula | C9H17NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Carfilzomib Impurity 43 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Carfilzomib Impurity 43 (CAS 247068-85-5) is a certified pharmaceutical impurity reference standard with the molecular formula C9H17NO2C2HF3O2 and a molecular weight of 285.26 g/mol.
The molecular framework of Carfilzomib Impurity 43 (C9H17NO2C2HF3O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Carfilzomib Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H17NO2 C2HF3O2 |
| Molecular Weight | 285.26 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Carfilzomib Standards
- CarfilzomiB impurity 12 (CAS 100564-78-1)
- Carfilzomib Impurity 36 (CAS 1140908-89-9)
- Carfilzomib Impurity 50 (CAS 129603-01-6)
- Carfilzomib Impurity N2 (CAS 1396006-45-3)
- Carfilzomib Impurity N1 (CAS 1396006-47-5)
- Carfilzomib Impurity 28 (CAS 143415-51-4)
- Carfilzomib Impurity 25 (CAS 15136-32-0)
- Carfilzomib Impurity 71 (CAS 1528769-14-3)
Recommended Standards
- Argatroban Impurity 125 (CAS CATO-C4X-1007125)
- Lincomycin Impurity 23 (CAS CATO-C4X-134223)
- Safinamide impurity 53 HCl (CAS CATO-C4X-159053)
- 4-Chloro-2-(methylamino)benzoic acid (CAS 54675-18-2)
- 4-[(4-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 379728-21-9)
- Nemonoxacin Impurity 117 (CAS CATO-C4X-3128117)
- 3-(1H-benzo[d][1,2,3]triazol-1-yl)butanoic acid (CAS 654-13-7)
- n-(2-Methylpropyl)-4-(trifluoromethyl)aniline (CAS 887590-06-9)
- (S)-1-(3-fluoro-5-methoxyphenyl)but-3-en-1-amine (CAS 1270116-70-5)
- Semaglutide impurity 48 (CAS CATO-C4X-222648)
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