Apremilast Impurity 112 CAS 247569-89-7
| CAS No. | 247569-89-7 |
| Molecular Formula | C10H13NO3 |
| Molecular Weight | 195.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Apremilast Impurity 112 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Apremilast Impurity 112 (CAS 247569-89-7), a pharmacopoeial impurity reference standard (molecular formula C10H13NO3, MW 195.22 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Apremilast Impurity 112 (C10H13NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Apremilast Impurity 112 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H13NO3 |
| Molecular Weight | 195.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 34 (CAS CATO-C4X-100934)
- Apremilast Impurity 47 (CAS 1956-36-1)
- Apremilast impurity 96 (CAS 856806-92-3)
- Apremilast impurity 97 (CAS 1000342-08-4)
- Apremilast Impurity 86 (CAS 106860-70-2)
- Apremilast Impurity N7 (CAS 2651-55-0)
- Apremilast Impurity 109 (CAS 2029-94-9)
- Apremilast Impurity 87 (CAS 202262-76-8)
Recommended Standards
- 3-Amino-4-(4-hydroxyphenyl)butyric Acid (CAS 64913-50-4)
- (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid (CAS 672-87-7)
- L-Tyrosine Methyl Ester (CAS 1080-06-4)
- Rivaroxaban Impurity 96 (CAS 1007650-38-5)
- Dexrazoxane Impurity 23 (CAS CATO-C4X-202023)
- Dotinurad Impurity 95 (CAS CATO-C4X-249495)
- Rabeprazole Impurity N1 (CAS 1163685-30-0)
- (S)-2-amino-N-(4-nitrobenzyl)propanamide (CAS 136774-66-8)
- Suzetrigine Impurity 55 (CAS CATO-C4X-336955)
- Tert-butyl 2-(tert-butyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (CAS 1330754-01-2)
- 2,4-Dichloro-6-(4-ethoxynaphthalen-1-yl)-1,3,5-triazine (CAS 21614-17-5)
- tert-Butyl 4-(quinazolin-4-ylthio)piperidine-1-carboxylate (CAS 325146-03-0)
- 3-Bromo-N-(furan-2-ylmethyl)aniline (CAS 1019478-96-6)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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