6-[2-(2-chloro-3-pyridyl)ethynyl]-1H-pyrido[2,3-d]pyrimidin-4-one CAS 2494962-77-3
| CAS No. | 2494962-77-3 |
| Molecular Formula | C14H7ClN4O |
| Molecular Weight | 282.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-[2-(2-chloro-3-pyridyl)ethynyl]-1H-pyrido[2,3-d]pyrimidin-4-one (CAS 2494962-77-3), molecular formula C14H7ClN4O and molecular weight 282.68 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-[2-(2-chloro-3-pyridyl)ethynyl]-1H-pyrido[2,3-d]pyrimidin-4-one (C14H7ClN4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 6-[2-(2-chloro-3-pyridyl)ethynyl]-1H-pyrido[2,3-d]pyrimidin-4-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H7ClN4O |
| Molecular Weight | 282.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 5-(2-(4-Chlorophenyl)hydrazono)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 81077-45-4)
- 6-[2-(2-chloro-4-pyridyl)ethynyl]-1H-pyrido[2,3-d]pyrimidin-4-one (CAS 2585151-47-7)
- 5-((2-Chlorobenzamido)methyl)-4,5-dihydroisoxazole-3-carboxylic acid (CAS 339101-05-2)
- 6-[2-(6-chloro-3-pyridyl)ethynyl]-1H-pyrido[2,3-d]pyrimidin-4-one (CAS 2607216-33-9)
- 2,2-Difluoro-1-(4-Fluorophenyl)-2-(Methylsulfanyl)Ethanone (CAS 192862-13-8)
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