Benzoic Acid impurity 6 CAS 2497-91-8
| CAS No. | 2497-91-8 |
| Molecular Formula | C7H3ClN2O6 |
| Molecular Weight | 246.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Benzoic Acid impurity 6 is closely related to a carbohydrate-derived structure, an amide group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Benzoic Acid impurity 6 (CAS 2497-91-8), a pharmacopoeial impurity reference standard (molecular formula C7H3ClN2O6, MW 246.56 g/mol) used for the identification and quantification of trace impurities in APIs.
Benzoic Acid impurity 6 (C7H3ClN2O6) contains a carbohydrate-derived structure, an amide group, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Benzoic Acid impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3ClN2O6 |
| Molecular Weight | 246.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Benzoic Standards
- Benzoic acid, 4-ethenyl-, 2,5-dioxo-1-pyrrolidinyl ester (CAS 97856-35-4)
- Benzoic acid, 4-bromo-3-(methoxy-d3)-, methyl ester (CAS 1352719-47-1)
- Benzoic (2S)-4-(hex-1-yn-1-yl)pyrrolidine-2-carboxylic anhydride (CAS 827028-11-5)
- Benzoic acid, 4-[[(tetrahydro-2H-pyran-4-yl)carbonyl]amino]- (CAS 1042816-00-1)
- Benzoic acid, 4-(aminosulfonyl)-, propyl ester (CAS 59777-58-1)
- Benzoic acid, 5-formyl-2-(2-methoxy-2-oxoethoxy)-, methyl ester (CAS 831217-47-1)
- Benzoic acid, 4-chloro-3-[(2-methyl-1-oxopropyl)amino]-, methyl ester (CAS 791802-72-7)
- Benzoic acid, 4-[(tetrahydro-2H-pyran-4-yl)methoxy]- (CAS 1008773-89-4)
Recommended Standards
- Bumetanide Impurity 14 (CAS 118-97-8)
- (6-Chloro-2,3-difluoro-4-(trifluoromethyl)phenyl)hydrazine (CAS 120769-98-4)
- 4-Chloro-2,6-dinitrobenzoic Acid (CAS 95192-57-7)
- (2-Chloro-3,5-difluoro-4-(trifluoromethyl)phenyl)hydrazine (CAS 121435-36-7)
- Pentoxyverine Impurity 2 (CAS CATO-C4X-22702)
- Tepotinib impurity 7 (CAS 1103507-26-1)
- Alectinib Impurity 36 (CAS CATO-C4X-283636)
- Phyllomedusin (CAS 26145-48-2)
- 2-Amino-5-chloro-α-(cyclopropylethynyl)-4-isopropylsilyloxy-α-(trifluoromethyl)benzenemethanol (CAS 1159977-02-2)
- Allobarbital (CAS 52-43-7)
- 3-Amino-4-hydroxybenzamide (CAS 120629-58-5)
- 3-(Difluoromethoxy)-N-(prop-2-yn-1-yl)benzamide (CAS 1147279-02-4)
- 5-Methyl-2,3-dihydro-1-benzofuran-3-amine (CAS 825-27-4)
- Semaglutide impurity 51 (CAS CATO-C4X-222651)
Why CATO?
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