Methyl 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-hydroxy-2-pyrrolidinecarboxylate CAS 251097-80-0
| CAS No. | 251097-80-0 |
| Molecular Formula | C12H12ClF3N2O3 |
| Molecular Weight | 324.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 324.68 g/mol gives Methyl 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-hydroxy-2-pyrrolidinecarboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Methyl 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-hydroxy-2-pyrrolidinecarboxylate (CAS 251097-80-0), a certified reference material (molecular formula C12H12ClF3N2O3, MW 324.68 g/mol) for analytical method development and quality control.
Structurally, Methyl 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-hydroxy-2-pyrrolidinecarboxylate (C12H12ClF3N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 324.68 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-4-hydroxy-2-pyrrolidinecarboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H12ClF3N2O3 |
| Molecular Weight | 324.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- 8-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)quinoline (CAS 1023544-22-0)
- 8-Chloro-3-phenyl-6-(trifluoromethyl)imidazo[1,5-a]pyridine-1-carbaldehyde (CAS 1708126-10-6)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole-3-carbaldehyde (CAS 338770-32-4)
- 4-[(E)-2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylidene}hydrazin-1-yl]benzonitrile (CAS 338420-08-9)
- N'-[5-chloro-2-nitro-4-(trifluoromethyl)phenyl]-N,N,N'-trimethylhydrazonoformamide (CAS 647824-57-5)
- 4'-Chloro-2,4-bis(trifluoromethyl)-1,1'-biphenyl (CAS 1333319-59-7)
- 2-(8-Chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7h-purin-7-yl)ethane-1-sulfonyl fluoride (CAS 877964-18-6)
- Ethyl 7-chloro-1-ethyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 70186-33-3)
Recommended Standards
- 2,2,2-Trifluoroethyl n-[2-chloro-5-(dimethylcarbamoyl)phenyl]carbamate (CAS 1306605-69-5)
- Azamethiphos (CAS 35575-96-3)
- 4-(Aminomethyl)-6-(difluoromethyl)-3-(trifluoromethyl)pyridine-2-sulfonyl chloride (CAS 1361887-11-7)
- 4-(Aminomethyl)-5-(difluoromethyl)-3-(trifluoromethyl)pyridine-2-sulfonyl chloride (CAS 1361869-36-4)
- N-(2,5-Dichlorobenzyl)propan-2-amine (CAS 1152879-31-6)
- 4,5-Dibromo-N-(2-hydroxy-4-methylphenyl)thiophene-2-carboxamide (CAS 875157-84-9)
- 6-(3,4-Dimethoxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (CAS 235100-56-8)
- Dasatinib Impurity 75 (CAS CATO-C4X-160775)
- 4-(2-Methoxyphenyl)pyrimidin-2-amine (CAS 915070-01-8)
- 2-(Ethoxycarbonyl)cyclopropanecarboxylic acid (CAS 167113-73-7)
- 3-(2-Hydroxyphenyl)-2-thioxothiazolidin-4-one (CAS 102878-38-6)
- 2-Bromo-4-difluoromethanesulfonyl-1-fluorobenzene (CAS 1672664-55-9)
- Tafluprost impurity 24 (CAS CATO-C4X-216324)
- Semaglutide impurity 104(Fmoc-D-His-Aib) (CAS 2171211-18-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com