(5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)(morpholino)methanone CAS 251310-48-2
| CAS No. | 251310-48-2 |
| Molecular Formula | C15H16ClF3N4O3 |
| Molecular Weight | 392.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 392.76 g/mol gives (5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)(morpholino)methanone distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)(morpholino)methanone (CAS 251310-48-2), molecular formula C15H16ClF3N4O3 and molecular weight 392.76 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)(morpholino)methanone (C15H16ClF3N4O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)(morpholino)methanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H16ClF3N4O3 |
| Molecular Weight | 392.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-4-methyl-2-phenylpyrimidine-5-carboxamide (CAS 338406-23-8)
- 4'-[(2-Chloro-5-Methylphenyl)Sulfonylamino]-2,2,2-Trifluoroacetanilide (CAS 64058-75-9)
- 3-Chloro-N-({3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 477867-49-5)
- 5-(5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 400082-28-2)
- 1-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-(morpholin-4-yl)ethan-1-one (CAS 338979-16-1)
- N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[(1-naphthylmethyl)amino]acetamide (CAS 329779-25-1)
- 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-5-[(2Z)-2-(methoxyimino)ethyl]-1,2-thiazole-4-carbonitrile (CAS 338413-08-4)
- 5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(p-tolyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (CAS 250714-13-7)
Recommended Standards
- Dimethyl 5-(2-chloro-5-nitrobenzamido)isophthalate (CAS 328258-97-5)
- Dimethyl 2-(4-chloro-3-nitrobenzamido)terephthalate (CAS 328258-36-2)
- 1,5-Di(triisopropylsilyl)-1,4-pentadiyn-3-ol (CAS 142761-84-0)
- Dimethyl 2-(2-chloro-4-nitrobenzamido)terephthalate (CAS 328258-80-6)
- (4-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid (CAS 1060794-98-0)
- 2-(4-Formyl-2-methoxyphenoxy)-N-[2-(trifluoromethyl)phenyl]acetamide (CAS 461652-60-8)
- 1-(2,2-Difluoroethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2246778-86-7)
- Lornoxicam Impurity 38 (CAS 937643-65-7)
- 3-((4,5-Dihydrothiazol-2-yl)amino)propanenitrile (CAS 300686-12-8)
- Dicyclohexylamine (R)-2-((tert-butoxycarbonyl)amino)-3-cyclopropylpropanoate (CAS 89483-09-0)
- 76372-75-3 2,9-Dipentylisoquinolino[4',5',6':6,5,10]anthra[2,1,9-def]isoquinoline-1,3,8,10(2H,9H)-tetrone DTXSID30506080 (CAS 76372-75-3)
- 2-methyl-1H-Indole-4-carboxylic acid ethanedioate (2:1) (CAS 1841081-57-9)
- Ethyl 3-chloro-6-fluorobenzo[b]thiophene-2-carboxylate (CAS 327980-05-2)
- Calcitonin C-Terminal Flanking Peptide (human) XTFA (CAS 85916-47-8（free base）)
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