5-Fluoro-2-(1h-imidazol-1-yl)aniline CAS 251649-52-2
| CAS No. | 251649-52-2 |
| Molecular Formula | C9H8FN3 |
| Molecular Weight | 177.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Fluoro-2-(1h-imidazol-1-yl)aniline.
5-Fluoro-2-(1h-imidazol-1-yl)aniline (CAS 251649-52-2) is a high-purity analytical reference standard with the molecular formula C9H8FN3 and a molecular weight of 177.18 g/mol.
The molecular framework of 5-Fluoro-2-(1h-imidazol-1-yl)aniline (C9H8FN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Fluoro-2-(1h-imidazol-1-yl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8FN3 |
| Molecular Weight | 177.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluoro Standards
- 5-Fluoro-2-(1h-pyrazol-1-yl)aniline (CAS 1006960-35-5)
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- 3-(3-Fluoro-4-methylphenyl)-3-oxopropanenitrile (CAS 1016770-89-0)
- 6-FLUORO-7-METHOXY-ISOQUINOLINE (CAS 1036711-00-8)
- 8-Fluoro-4-methylisoquinolin-1(2H)-one (CAS 1050203-45-6)
- 6-Fluoro-8-methylquinolin-4-ol (CAS 1065092-74-1)
- 7-Fluoro-8-methylquinolin-4-ol (CAS 1065092-79-6)
- 6-Fluoro-8-hydroxy-2-methylquinoline (CAS 1070897-08-3)
Recommended Standards
- 5-Fluoro-1-methyl-1h-indole-3-carbaldehyde (CAS 441715-30-6)
- 5-Fluoro-2-methyl-1H-indole-3-carbaldehyde (CAS 815586-68-6)
- 5-Fluoro-1-methyl-1H-indole-2-carbaldehyde (CAS 883531-48-4)
- 5-Fluoro-2-methylquinolin-8-ol (CAS 37026-20-3)
- 4-Hydroxy-5-oxotetrahydrofuran-3-carboxylic acid (CAS 118489-44-4)
- N-(6-Chloro-2-pyridinyl)-N,N-dipropylamine (CAS 1219972-08-3)
- (2-Bromobutyl)benzene (CAS 81012-82-0)
- 3-(2-Phenyl-1H-imidazol-1-yl)propan-1-amine dihydrochloride (CAS 93668-45-2)
- Olmesartan Impurity 69 (CAS 129482-56-0)
- 1-(2-(hydroxymethyl)phenyl)ethanone (CAS 32521-21-4)
- N-(4-(p-Tolyl)-1H-imidazol-2-yl)acetamide (CAS 160041-65-6)
- Vilanterol Impurity 40 (CAS 503070-57-3)
- Ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate (CAS 1005883-72-6)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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