Tadalafil EP Impurity E CAS 2520114-41-2
| CAS No. | 2520114-41-2 |
| Molecular Formula | C22H19N3O6 |
| Molecular Weight | 421.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Tadalafil EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 421.40 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Tadalafil EP Impurity E (CAS 2520114-41-2, C22H19N3O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H19N3O6 |
| Molecular Weight | 421.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
- Tadalafil Impurity 167 (CAS CATO-C4X-1087167)
- Tadalafil EP Impurity D (CAS CATO-C4X-10874)
- Tadalafil EP Impurity F (CAS 2747958-44-5)
- Tadalafil EP Impurity H (CAS 1978322-98-3)
- Tadalafil Impurity 32 (CAS CATO-C4X-108732)
- Tadalafil Impurity 62 (CAS CATO-C4X-108762)
- Tadalafil Impurity 82 (CAS CATO-C4X-108782)
- Tadalafil Impurity 162 (CAS CATO-C4X-1087162)
Recommended Standards
- Vonoprazan Impurity 296 (CAS CATO-C4X-1020296)
- Rivaroxaban Impurity 100 (CAS CATO-C4X-1090100)
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- Rivaroxaban Impurity 104（Enantiomer Mixture） (CAS 1265617-06-8)
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- 2-(3-Chloro-4-fluorophenyl)ethane-1-thiol (CAS 1314976-65-2)
- Semaglutide Impurity 14(Discontinued,See CPTD788307 ) (CAS CATO-C4X-222614)
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