2-amino-4,4-difluorobutanoic acid hydrochloride CAS 252357-32-7
| CAS No. | 252357-32-7 |
| Molecular Formula | C4H7F2NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 175.56 g/mol gives 2-amino-4,4-difluorobutanoic acid hydrochloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-amino-4,4-difluorobutanoic acid hydrochloride (CAS 252357-32-7), molecular formula C4H7F2NO2HCl and molecular weight 175.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-amino-4,4-difluorobutanoic acid hydrochloride (C4H7F2NO2HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-amino-4,4-difluorobutanoic acid hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H7F2NO2 HCl |
| Molecular Weight | 175.56 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 2,2,4,4-Tetrafluoro-4H-benzo[d][1,3]dioxin-6-amine (CAS 25854-59-5)
- methyl 5-(hydroxymethyl)-2-methyl-pyrazole-3-carboxylate (CAS 1208081-25-7)
- 3-Hydroxy-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoic acid (CAS 101004-94-8)
- Cenobamate impurity 10 (CAS CATO-C4X-241610)
- 3-EThylbenzo[d][1,2,3]triazin-4(3h)-one (CAS 26944-60-5)
- 2-(Isopropylamino)-3-(5-methyl-1h-pyrazol-1-yl)propanamide (CAS 1342706-43-7)
- 1-Methyl-1H-indole-7-sulfonamide (CAS 2168249-75-8)
- 2-(chloromethyl)-5-fluoro-pyridine hydrochloride (CAS 915409-01-7)
- (1E)-1-[2-(Ethylsulfanyl)-1-methyl-1H-imidazol-5-yl]-N-(4-methoxyphenyl)methanimine (CAS 303986-81-4)
- Liraglutide Impurity 25 (CAS CATO-C4X-199225)
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