3-Chloro-4-hydroxybenzenesulfonyl chloride CAS 25319-94-2
| CAS No. | 25319-94-2 |
| Molecular Formula | C6H4Cl2O3S |
| Molecular Weight | 227.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-4-hydroxybenzenesulfonyl chloride (CAS 25319-94-2) is a high-purity analytical reference standard with the molecular formula C6H4Cl2O3S and a molecular weight of 227.07 g/mol.
Based on its molecular formula C6H4Cl2O3S, 3-Chloro-4-hydroxybenzenesulfonyl chloride contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 227.07 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4Cl2O3S |
| Molecular Weight | 227.07 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-5-hydroxybenzenesulfonyl Chloride (CAS 1261449-72-2)
- 4-Chloro-2-hydroxybenzene-1-sulfonyl chloride (CAS 1261514-57-1)
- 2-Chloro-6-hydroxybenzene-1-sulfonyl chloride (CAS 1261568-90-4)
- 3-Chloro-2-hydroxybenzene-1-sulfonyl chloride (CAS 1261585-06-1)
- 4-chloro-3-hydroxybenzene-1-sulfonyl chloride (CAS 1261761-11-8)
- 5-Chloro-2-hydroxybenzene-1-sulfonyl chloride (CAS 25319-95-3)
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Recommended Standards
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- 1H-Pyrrolo[3,4-d]pyrimidin-4-ol (CAS 39455-98-6)
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