5-Chloro-2-hydroxybenzene-1-sulfonyl chloride CAS 25319-95-3
| CAS No. | 25319-95-3 |
| Molecular Formula | C6H4Cl2O3S |
| Molecular Weight | 227.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-Chloro-2-hydroxybenzene-1-sulfonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-Chloro-2-hydroxybenzene-1-sulfonyl chloride (CAS 25319-95-3), molecular formula C6H4Cl2O3S and molecular weight 227.07 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-2-hydroxybenzene-1-sulfonyl chloride (C6H4Cl2O3S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H4Cl2O3S |
| Molecular Weight | 227.07 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-5-hydroxybenzenesulfonyl Chloride (CAS 1261449-72-2)
- 4-Chloro-2-hydroxybenzene-1-sulfonyl chloride (CAS 1261514-57-1)
- 2-Chloro-6-hydroxybenzene-1-sulfonyl chloride (CAS 1261568-90-4)
- 3-Chloro-2-hydroxybenzene-1-sulfonyl chloride (CAS 1261585-06-1)
- 4-chloro-3-hydroxybenzene-1-sulfonyl chloride (CAS 1261761-11-8)
- 3-Chloro-4-hydroxybenzenesulfonyl chloride (CAS 25319-94-2)
- 4-Chloro-3-(2-chloroethyl)cinnoline (CAS 131110-40-2)
- 4-Chloro-2-(chloromethyl)-6-methylquinazoline (CAS 147006-37-9)
Recommended Standards
- 4-Chlorophenyl chloranesulfonate (CAS 32117-86-5)
- Methyl 4,5-dichloro-3-hydroxythiophene-2-carboxylate (CAS 96232-70-1)
- 4,6-Dichloro-2-methylsulfonylpyrimidine (CAS 4489-34-3)
- 6-Bromo-2-oxo-1,2,3,4-tetrahydro-2lambda4-isoquinoline (CAS 147497-32-4)
- 3-Hydroxy-2-oxo-7-indolinesulfonic acid (CAS 1353501-00-4)
- 1-Benzyl-3-(methoxycarbonyl)-4-piperidone (CAS 57611-47-9)
- N-Benzyl-3-(1,3-dioxoisoindolin-2-yl)propanamide (CAS 4905-27-5)
- cis-3-methoxycyclohexanol (CAS 16327-00-7)
- N-(4-Chlorophenyl)-3-phenylacrylamide (CAS 53691-91-1)
- 4-(((9H-Fluoren-9-yl)methoxy)carbonyl)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylicacid (CAS 218278-58-1)
- 3-Bromo-5-phenylthiophene-2-carboxylic acid (CAS 1017687-42-1)
- Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 3-amino-4,6-dihydro-6,6-dimethyl-1-(1-oxopropoxy)-, 1,1-dimethylethyl ester (CAS 2007915-99-1)
- 3-(3'-Chloro-[1,1'-biphenyl]-4-yl)propanoic acid (CAS 893641-22-0)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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