(alphaR,5alpha,7alpha)-4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-6,14-ethenomorphinan-7-methanol19-Propylorvinol, 3-acetate hydrochlorideEtorphine 3-acetate hydrochloride CAS 25333-78-2
| CAS No. | 25333-78-2 |
| Molecular Formula | C27H35NO5 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(alphaR,5alpha,7alpha)-4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-6,14-ethenomorphinan-7-methanol19-Propylorvinol, 3-acetate hydrochlorideEtorphine 3-acetate hydrochloride (CAS 25333-78-2), molecular formula C27H35NO5HCl and molecular weight 490.04 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, (alphaR,5alpha,7alpha)-4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-6,14-ethenomorphinan-7-methanol19-Propylorvinol, 3-acetate hydrochlorideEtorphine 3-acetate hydrochloride (C27H35NO5HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 490.04 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H35NO5 HCl |
| Molecular Weight | 490.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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