Naftidrofuryl impurity 1 CAS 25379-26-4
| CAS No. | 25379-26-4 |
| Molecular Formula | C18H20O3 |
| Molecular Weight | 284.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Naftidrofuryl impurity 1 (CAS 25379-26-4) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20O3 and a molecular weight of 284.35 g/mol.
The molecular framework of Naftidrofuryl impurity 1 (C18H20O3) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20O3 |
| Molecular Weight | 284.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
Related Naftidrofuryl Standards
- Naftidrofuryl EP impurity B (CAS 35997-58-1)
- Naftidrofuryl EP impurity D (CAS 77454-16-1)
- Naftidrofuryl EP impurity E (CAS 3216-60-2)
- Naftidrofuryl EP Impurity F (CAS 41359-72-2)
- Naftidrofuryl (CAS 31329-57-4)
- Naftidrofuryl-D4 (CAS 1215649-28-7)
- Naftidrofuryl EP Impurity C (CAS 115025-98-4)
- Naftidrofuryl Oxalate Impurity C (CAS 115025-99-5)
Recommended Standards
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- Albendazole sulfoxide-d3 (CAS 1448346-38-0)
- Picosulfate impurity 23 (CAS 158839-52-2)
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- N-Nitroso Flucloxacillin Impurity 22 (CAS CATO-C4X-164722)
- (alphaS,betaR)-Bedaquiline (CAS 843663-66-1)
- 1-Methyl-1H-indazole-5,6-diamine (CAS 724766-98-7)
- 3-Propyl-1H-indol-6-ol (CAS 820960-40-5)
- 3-(Piperidine-1-carbonyl)benzoic acid (CAS 194738-09-5)
- 2-(Dibenzo[b,d]furan-2-carbonyl)benzoic acid (CAS 56260-28-7)
- N-(4-chlorophenyl)propanethioamide (CAS 35274-18-1)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
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