Naftidrofuryl EP impurity D CAS 77454-16-1
| CAS No. | 77454-16-1 |
| Molecular Formula | C13H25NO3 |
| Molecular Weight | 243.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Naftidrofuryl EP impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Naftidrofuryl EP impurity D (CAS 77454-16-1), a pharmacopoeial impurity reference standard (molecular formula C13H25NO3, MW 243.34 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Naftidrofuryl EP impurity D (C13H25NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H25NO3 |
| Molecular Weight | 243.34 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 1 |
Related Naftidrofuryl Standards
- Naftidrofuryl impurity 1 (CAS 25379-26-4)
- Naftidrofuryl EP impurity B (CAS 35997-58-1)
- Naftidrofuryl EP impurity E (CAS 3216-60-2)
- Naftidrofuryl EP Impurity F (CAS 41359-72-2)
- Naftidrofuryl (CAS 31329-57-4)
- Naftidrofuryl-D4 (CAS 1215649-28-7)
- Naftidrofuryl EP Impurity C (CAS 115025-98-4)
- Naftidrofuryl Oxalate Impurity C (CAS 115025-99-5)
Recommended Standards
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