Doxofylline Impurity 19 CAS 254760-82-2
| CAS No. | 254760-82-2 |
| Molecular Formula | C11H16N4O4 |
| Molecular Weight | 268.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Doxofylline Impurity 19 (CAS 254760-82-2) is a certified pharmaceutical impurity reference standard with the molecular formula C11H16N4O4 and a molecular weight of 268.27 g/mol.
The molecular framework of Doxofylline Impurity 19 (C11H16N4O4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Doxofylline Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H16N4O4 |
| Molecular Weight | 268.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 4 |
Related Doxofylline Standards
- Doxofylline Impurity 6 (CAS 1429636-72-5)
- Doxofylline Impurity 7 (CAS CATO-C4X-15137)
- Doxofylline-d4 (CAS 1346599-13-0)
- Doxofylline (CAS 69975-86-6)
- Doxofylline Impurity 14 (CAS 7029-96-1)
- Doxofylline Impurity 3 (CAS 1174289-18-9)
- Doxofylline impurity 45 (CAS 96474-41-8)
- Doxofylline-d6 (dimethyl-d6) (CAS 1219805-99-8)
Recommended Standards
- Oxcarbazepine Impurity 25 (CAS 104839-39-6)
- 6-(4-methoxybenzyl)-6H-pyrrolo[3,4-B]pyridine-5,7-dione (CAS 442882-27-1)
- Dexrazoxane (CAS 24584-09-6)
- 35098-52-3 Propionamide, N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, D-threo- BU 2000 D-threo-1-p-Nitrophenyl-2-propionamido-1,3-propanediol (CAS 35098-52-3)
- Benidipine Impurity N50 (CAS 1353946-52-7)
- Caspofungin Impurity 9 (CAS CATO-C4X-157511)
- Maxacalcitol Impurity 50 (CAS CATO-C4X-151050)
- 2-chloro-N-[4-(4-methylpiperidin-1-yl)phenyl]acetamide hydrochloride (CAS 1052089-51-6)
- 2-amino-2-(trifluoromethyl)butanoic acid hydrochloride (CAS 1427379-54-1)
- Diosgenin-3-O-�-D-xylosyl-(1?3)-�-glucoside (CAS 65604-99-1)
- Ethyl 2-(tert-butyl)-5-hydroxybenzofuran-3-carboxylate (CAS 384359-45-9)
- 3-Methoxytetrafluoropropanenitrile (CAS 77946-88-4)
- 3-Nitro-2-((1-(3-nitropyridin-2-yl)-1H-1,2,4-triazol-3-yl)thio)pyridine (CAS 251307-22-9)
- D-Ile12-Tirzepatide (CAS CATO-CPTD788921)
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