4-Bromo-5-methylisothiazol-3(2H)-one CAS 25629-53-2

Description

Compared with other compounds in its class, the molecular weight of 194.05 g/mol gives 4-Bromo-5-methylisothiazol-3(2H)-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

4-Bromo-5-methylisothiazol-3(2H)-one (CAS 25629-53-2) is a high-purity analytical reference standard with the molecular formula C4H4BrNOS and a molecular weight of 194.05 g/mol.

The molecular framework of 4-Bromo-5-methylisothiazol-3(2H)-one (C4H4BrNOS) is characterized by an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-Bromo-5-methylisothiazol-3(2H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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