4-(Difluoromethyl)pyrimidin-2-amine hydrochloride CAS 2573216-38-1
| CAS No. | 2573216-38-1 |
| Molecular Formula | C5H5F2N3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(Difluoromethyl)pyrimidin-2-amine hydrochloride is closely related to a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(Difluoromethyl)pyrimidin-2-amine hydrochloride (CAS 2573216-38-1), molecular formula C5H5F2N3HCl and molecular weight 181.57 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-(Difluoromethyl)pyrimidin-2-amine hydrochloride (C5H5F2N3HCl) contains a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 181.57 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Difluoromethyl)pyrimidin-2-amine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F2N3 HCl |
| Molecular Weight | 181.57 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Difluoromethyl Standards
- 2-(2-(Difluoromethyl)phenyl)acetic acid (CAS 1000517-62-3)
- 2-[4-(difluoromethyl)phenyl]acetic acid (CAS 1000524-74-2)
- 2-(4-(Difluoromethyl)phenyl)acetonitrile (CAS 1000529-64-5)
- 2-(3-(Difluoromethyl)phenyl)acetonitrile (CAS 1000529-78-1)
- 2-(4-(Difluoromethyl)phenyl)ethan-1-amine (CAS 1000539-08-1)
- 2-(3-(Difluoromethyl)phenyl)acetic acid (CAS 1000547-15-8)
- 2-(2-(Difluoromethyl)phenyl)acetonitrile (CAS 1000556-48-8)
- 2-(2-(Difluoromethyl)phenyl)ethanamine (CAS 1000559-85-2)
Recommended Standards
- 2-Hydrazinyl-5,6,7,8-tetrahydroquinoline (CAS 937677-75-3)
- (5-Bromo-2-fluorophenyl)(cyclopropyl)methanamine (CAS 1270377-73-5)
- 3-(1H-Imidazol-5-yl)propyl carbamimidothioate (CAS 102203-17-8)
- 7-Bromo-6,8-dichloroquinazolin-4(3H)-one (CAS 1698027-56-3)
- 3-(4-(4-Phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)-1H-indole-5-carboxylic acid (CAS 98323-83-2)
- 2-Chloro-4-cyclopropoxy-5-iodopyridine (CAS 1243473-95-1)
- 2-(Aminomethyl)-6-(difluoromethyl)-3-(trifluoromethoxy)pyridine-5-sulfonamide (CAS 1805228-14-1)
- 1-(2-Chloroethyl)-2-ethyl-1H-imidazole hydrochloride (CAS 1158269-27-2)
- 2-Amino-3,5-di-tert-butylbenzaldehyde (CAS 728042-52-2)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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