Methyl 2-(3-amino-4-fluorophenyl)acetate CAS 257632-77-2
| CAS No. | 257632-77-2 |
| Molecular Formula | C9H10FNO2 |
| Molecular Weight | 183.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Methyl 2-(3-amino-4-fluorophenyl)acetate (CAS 257632-77-2), molecular formula C9H10FNO2 and molecular weight 183.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 2-(3-amino-4-fluorophenyl)acetate (C9H10FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H10FNO2 |
| Molecular Weight | 183.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- methyl 2-amino-4-fluoro-5-methylbenzoate (CAS 1037206-86-2)
- 2-Amino-2-(2-fluoro-4-methylphenyl)acetic acid (CAS 1039118-67-6)
- 2-Amino-2-(5-fluoro-2-methylphenyl)acetic acid (CAS 1039365-71-3)
- 2-Amino-2-(4-fluoro-2-methylphenyl)acetic acid (CAS 1039620-35-3)
- 1-(2-amino-3-fluoro-4-methoxyphenyl)ethan-1-one (CAS 1073119-05-7)
- Methyl 3-amino-5-fluoro-4-methylbenzoate (CAS 1093087-06-9)
- Ethyl 2-amino-6-fluorobenzoate (CAS 1108668-11-6)
- Ethyl 2-amino-4-fluorobenzoate (CAS 117324-05-7)
Recommended Standards
- Methyl 2-(2-amino-5-fluorophenyl)acetate (CAS 29641-00-7)
- Methyl 2-amino-2-(2-fluorophenyl)acetate (CAS 573701-88-9)
- HOMOCYSTEIC ACID, DL- (CAS 504-33-6)
- Methyl 2-amino-2-(3-fluorophenyl)acetate (CAS 742640-44-4)
- 5-(Methylamino)-1,3,4-thiadiazole-2-carboxylic acid (CAS 89033-43-2)
- 4-Bromo-3,5-difluorophenol (CAS 130191-91-2)
- 1-(3-methyl-1,2-oxazol-5-yl)cyclopropane-1-carboxylic acid (CAS 1469286-26-7)
- [4-(4-methoxyphenoxy)phenyl]methanol (CAS 70151-68-7)
- 2-Methylhepta-1,5-diene (CAS 6766-54-7)
- (E)-N'-(5-Bromo-2-fluorobenzylidene)-2-(trifluoromethyl)benzenesulfonohydrazide (CAS 2301998-92-3)
- 4-Cyclopropoxy-3,5-diisopropylpyridine (CAS 1243456-87-2)
- 1-Bromo-2-(2-bromo-1-(2-ethoxyethoxy)ethyl)benzene (CAS 1247216-71-2)
- N-(3,5-Dimethoxyphenyl)-3-phenylcinnoline-4-carboxamide (CAS 883004-78-2)
- Biotinyl-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 213779-13-6)
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