4-Methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride CAS 257876-11-2
| CAS No. | 257876-11-2 |
| Molecular Formula | C9H6ClN3OS |
| Molecular Weight | 239.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride (C9H6ClN3OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-Methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride (CAS 257876-11-2), molecular formula C9H6ClN3OS and molecular weight 239.68 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H6ClN3OS |
| Molecular Weight | 239.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 4-Chloro-2-oxo-3-phenyl-2,3-dihydro-thiazole-5-carbaldehyde (CAS 324060-92-6)
- 5-Chloro-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide (CAS 2142576-45-0)
- (R)-1-(3-fluoro-5-methoxyphenyl)pentan-1-amine (CAS 1212815-53-6)
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- N-(2-Nitrophenylsulfenyl)-L-tyrosine (dicyclohexylammonium) salt (CAS 7675-56-1)
- Glycolic acid-Threonine-Octreotide (CAS CATO-C4X-152019)
- tert-Butyl methyl(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)carbamate (CAS 1956327-78-8)
- 2-Bromo-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethanone (CAS 4629-54-3)
- (R)-2-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-1-(trityloxy)but-3-en-2-ol (CAS 865838-12-6)
- 6-Bromospiro[indoline-3,3'-pyrrolidin]-2-one hydrochloride (CAS 2247105-73-1)
- tert-butyl 3-amino-3-carbamoylazetidine-1-carboxylate (CAS 1254120-14-3)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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